Serum protein corona-responsive autophagy tuning in cells

doi:10.1039/c8nr05770b

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Serum protein corona-responsive autophagy tuning in cells
	Kong, HT ; Xia, K ; Ren, N ; Cui, YZ ; Liu, RD ; Li, QN ; Lv, M ; Shi, JY ; Yan, QL ; Cui, ZF
刊名	NANOSCALE
	2018
卷号	10 期号:37 页码:18055-18063
关键词	CARBON NANOTUBES SILVER NANOPARTICLES QUANTUM DOTS CYTOTOXICITY OXIDE DEPENDENCE CHEMISTRY PEPTIDES DISEASE IMPACT
ISSN号	2040-3364
DOI	10.1039/c8nr05770b
文献子类	期刊论文
英文摘要	Autophagy represents an important cellular response to nanoparticles (NPs), whose modulation holds great promise for developing nanomedicine. Here, we systematically studied cell autophagy responses elicited by the NP-protein corona with diverse protein corona types surrounding NPs with different sizes, shapes, and compositions. We demonstrated that these physicochemical properties of NP-protein coronas exerted a remarkable influence on cell autophagy responses. Particularly, for surface protein type-associated modulation of cell autophagy, we correlated the autophagy level to adsorbed protein type on Fe3O4 NPs. Accordingly, we could modulate cell autophagy in response to various levels of protein adsorption. Our work provides new clues to modulate cell autophagy by rational designing NP-protein complexes, which could aid in further biological and therapeutic applications.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31101]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Bioimaging Ctr,Shanghai Synchrotron Radiat Facil, Shanghai 201800, Peoples R China 2.Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Appl Phys, Div Phys Biol, Shanghai 201800, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China 4.UCB Pharma, 208 Bath Rd, Slough SL1 3WE, Berks, England
推荐引用方式 GB/T 7714	Kong, HT,Xia, K,Ren, N,et al. Serum protein corona-responsive autophagy tuning in cells[J]. NANOSCALE,2018,10(37):18055-18063.
APA	Kong, HT.,Xia, K.,Ren, N.,Cui, YZ.,Liu, RD.,...&Wang, LH.(2018).Serum protein corona-responsive autophagy tuning in cells.NANOSCALE,10(37),18055-18063.
MLA	Kong, HT,et al."Serum protein corona-responsive autophagy tuning in cells".NANOSCALE 10.37(2018):18055-18063.