Material distributions and functional structures in probiotic microcapsules

doi:10.1016/j.ejps.2018.06.013

CORC > 上海应用物理研究所 > 中国科学院上海应用物理研究所 > 中科院上海应用物理研究所2011-2017年

	Material distributions and functional structures in probiotic microcapsules
	Wu, L ; Qin, W ; He, YZ ; Zhu, WF ; Ren, XH ; York, P ; Xiao, TQ ; Yin, XZ ; Zhang, JW
刊名	EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
	2018
卷号	122 期号:-页码:1-8
关键词	X-RAY MICROTOMOGRAPHY SIMULATED GASTROINTESTINAL CONDITIONS OSMOTIC PUMP TABLETS CONTROLLED-RELEASE VIABILITY PREVENTION RADIATION BIFIDOBACTERIA ENCAPSULATION MICROSPHERES
ISSN号	0928-0987
DOI	10.1016/j.ejps.2018.06.013
文献子类	期刊论文
英文摘要	Smart microstructure design of dosage forms such as microcapsules that protect the microorganism, can improve probiotics survival from gastric pH challenges and prolong their shelf life. In this study, synchrotron radiation Xray microcomputed tomography (SR-mu CT) was applied to quantitatively reveal the material distributions and functional structures of bifidobacterium and lactobacillus microcapsules. The shell layer, middle protective layer, and the microorganisms as particles in the center layer were extracted and visualized. All the microorganisms were encapsulated by the shell completely, which prevents them from being destroyed by external environments. However, the non-uniform thickness of the shell and typical defects in the microcapsules were observed. The quantitative analysis and characterization of internal microstructures provide evidence of the need for further improvement in formulations and processing technologies for the structured system to deliver living microorganisms.
语种	英语
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/31022]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
作者单位	1.Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai Synchrotron Radiat Facil, Shanghai 201204, Peoples R China 2.Jiangxi Univ Tradit Chinese Med, Minist Educ, Key Lab Modern Preparat TCM, Nanchang 330004, Jiangxi, Peoples R China 3.Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England 4.Yantai Univ, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China 5.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China
推荐引用方式 GB/T 7714	Wu, L,Qin, W,He, YZ,et al. Material distributions and functional structures in probiotic microcapsules[J]. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,2018,122(-):1-8.
APA	Wu, L.,Qin, W.,He, YZ.,Zhu, WF.,Ren, XH.,...&Zhang, JW.(2018).Material distributions and functional structures in probiotic microcapsules.EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES,122(-),1-8.
MLA	Wu, L,et al."Material distributions and functional structures in probiotic microcapsules".EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES 122.-(2018):1-8.