Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition

doi:10.1177/1352458518788218

	Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition
	Lin, Fuchun 1,4; Zivadinov, Robert 1,3; Hagemeier, Jesper 1; Weinstock-Guttman, Bianca 1; Vaughn, Caila 1; Gandhi, Sirin 1; Jakimovski, Dejan 1; Hulst, Hanneke E.2; Benedict, Ralph H. B.1; Bergsland, Niels 1
刊名	MULTIPLE SCLEROSIS JOURNAL
	2019-08-01
卷号	25 期号:9 页码:1243-1254
关键词	Multiple sclerosis thalamus functional connectivity nuclei-specific fatigue cognition
ISSN号	1352-4585
DOI	10.1177/1352458518788218
英文摘要	Background: The thalamus, affected early in multiple sclerosis (MS), is a heterogeneous composition of functionally distinct nuclei and is associated with fatigue, cognition, and other outcomes. However, most previous functional imaging studies considered the thalamus only as a whole. Objective: To investigate MS-related abnormalities in nuclei-specific thalamic functional connectivity (FC) and their associations with fatigue and cognitive outcomes. Methods: Resting-state functional magnetic resonance imaging (fMRI) was analyzed in 64 MS patients and 26 healthy controls (HC). Whole-brain FC maps for four thalamic subregions seeds were computed for each subject. FC maps were compared between groups, and group by FC interaction effects were assessed for fatigue and cognitive measures. Results: MS patients had decreased FC between the left medial thalamic nuclei and left angular gyrus and reduced FC between the left posterior thalamic nuclei and left supramarginal gyrus, as well as decreased right medial thalamic nuclei connectivity with bilateral caudate/thalamus and left cerebellar areas (p < 0.05 corrected). MS patients had increased FC between the left anterior thalamic nuclei and anterior cingulate cortex bilaterally. There were significant relationships between connectivity alterations and fatigue and cognitive measures between groups (p < 0.05 corrected). Conclusion: FC alteration is nuclei-specific and is differentially associated with fatigue and cognition.
资助项目	Buffalo Neuroimaging Analysis Center
WOS关键词	RESTING-STATE NETWORK ; BRAIN CONNECTIVITY ; DYSFUNCTION ; CEREBELLUM ; ACTIVATION ; ATROPHY ; CORTEX ; MS
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000478623000009
资助机构	Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center ; Buffalo Neuroimaging Analysis Center
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/14729]
专题	中国科学院武汉物理与数学研究所
通讯作者	Dwyer, Michael G.
作者单位	1.SUNY Buffalo, Dept Neurol, Buffalo Neuroimaging Anal Ctr, Jacobs Sch Med & Biomed Sci, 100 High St, Buffalo, NY 14203 USA 2.Vrije Univ Amsterdam Med Ctr, Dept Anat & Neurosci, Amsterdam, Netherlands 3.SUNY Buffalo, Jacobs Sch Med & Biomed Sci, MRI Clin & Translat Res Ctr, Buffalo, NY USA 4.Chinese Acad Sci, Natl Ctr Magnet Resonance Wuhan, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Lin, Fuchun,Zivadinov, Robert,Hagemeier, Jesper,et al. Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition[J]. MULTIPLE SCLEROSIS JOURNAL,2019,25(9):1243-1254.
APA	Lin, Fuchun.,Zivadinov, Robert.,Hagemeier, Jesper.,Weinstock-Guttman, Bianca.,Vaughn, Caila.,...&Dwyer, Michael G..(2019).Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition.MULTIPLE SCLEROSIS JOURNAL,25(9),1243-1254.
MLA	Lin, Fuchun,et al."Altered nuclei-specific thalamic functional connectivity patterns in multiple sclerosis and their associations with fatigue and cognition".MULTIPLE SCLEROSIS JOURNAL 25.9(2019):1243-1254.