Constraint induced movement therapy promotes contralesional-oriented structural and bihemispheric functional neuroplasticity after stroke

doi:10.1016/j.brainresbull.2019.06.003

	Constraint induced movement therapy promotes contralesional-oriented structural and bihemispheric functional neuroplasticity after stroke
	Liu, Peile 1; Li, Ce 1; Zhang, Bei 1; Zhang, Zhijian 2; Gao, Beiyao 1; Liu, Yue 2; Wang, Yuyuan 3; Hua, Yan 1; Hu, Jian 1; Qiu, Xiao 3
刊名	BRAIN RESEARCH BULLETIN
	2019-08-01
卷号	150 页码:201-206
关键词	Stroke rehabilitation Constraint-induced movement therapy Retrograde nerve tracing Neural plasticity
ISSN号	0361-9230
DOI	10.1016/j.brainresbull.2019.06.003
英文摘要	The mechanism behind constraint-induced movement therapy (CIMT) in promoting motor recovery after stroke remains unclear. We explored the bilateral structural and functional reorganization of the brain induced by CIMT after left middle cerebral artery occlusion (MCAO) in rats. CIMT started on the 8th day (D8) after MCAO surgery and lasted for 3 weeks. Skilled walking was assessed by Foot-Fault tests. The efferent neuron network innervating the paralyzed forelimb was labeled by pseudorabies virus (PRV) to explore neuron recruitment. Synapsin I was used as an indicator of the number of synapses. Additionally, C-fos expression 1 h after walking was detected to explore the activation of the brain. As a result, CIMT significantly improved skilled walking and elicited more neuron recruitment into the innervating network of a paralyzed forelimb in the contralesional rather than the ipsilesional motor cortex and red nucleus. CIMT also increased the synapse number in the contralesional cortex but there was no corresponding effect in the intact ipsilesional cortex. Furthermore, MCAO decreased ipsilesional motor cortex activation, but CIMT partially compensated for this by increasing the number of activated neurons (c-fos(+)) in both the left and right motor cortex. In conclusion, the contralesional motor cortex and red nucleus might play more important roles than corresponding ipsilesional regions in structural reorganization during CIMT-induced motor recovery after stroke. However, CIMT promotes bilateral motor cortex activity without a side preference.
资助项目	National Natural Science Foundation of China[81871841] ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital[20154Y0047]
WOS关键词	PRIMARY MOTOR CORTEX ; CORTICOSPINAL TRACT ; C-FOS ; RECOVERY ; STIMULATION ; EXPRESSION ; PLASTICITY ; INJURY ; LESION ; MODEL
WOS研究方向	Neurosciences & Neurology
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000477784800021
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital ; health research project of health and family planning commission of Shanghai for Shanghai Third Rehabilitation hospital
内容类型	期刊论文
源URL	[http://ir.wipm.ac.cn/handle/112942/14687]
专题	中国科学院武汉物理与数学研究所
通讯作者	Qiu, Xiao; Bai, Yulong
作者单位	1.Fudan Univ, Dept Rehabil Med, Huashan Hosp, 12 Urumqi Middle Rd, Shanghai 200041, Peoples R China 2.Chinese Acad Sci, State Key Lab Magnet Resonance & Atom & Mol Phys, Key Lab Magnet Resonance Biol Syst, Wuhan Ctr Magnet Resonance,Wuhan Inst Phys & Math, Wuhan 430071, Hubei, Peoples R China 3.Fudan Univ, Huashan North Hosp, Dept Rehabil Med, 108 Luxiang Rd, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Liu, Peile,Li, Ce,Zhang, Bei,et al. Constraint induced movement therapy promotes contralesional-oriented structural and bihemispheric functional neuroplasticity after stroke[J]. BRAIN RESEARCH BULLETIN,2019,150:201-206.
APA	Liu, Peile.,Li, Ce.,Zhang, Bei.,Zhang, Zhijian.,Gao, Beiyao.,...&Bai, Yulong.(2019).Constraint induced movement therapy promotes contralesional-oriented structural and bihemispheric functional neuroplasticity after stroke.BRAIN RESEARCH BULLETIN,150,201-206.
MLA	Liu, Peile,et al."Constraint induced movement therapy promotes contralesional-oriented structural and bihemispheric functional neuroplasticity after stroke".BRAIN RESEARCH BULLETIN 150(2019):201-206.