First total synthesis of rhuscholide A, glabralide B and denudalide

doi:10.1016/j.tetlet.2019.151059

	First total synthesis of rhuscholide A, glabralide B and denudalide
	Li, Tian-Ze 1; Geng, Chang-An1 ; Chen, Ji-Jun1,2
刊名	TETRAHEDRON LETTERS
	2019-09-19
卷号	60 期号:38 页码:4
关键词	Total synthesis Rhuscholide A Glabralide B Denudalide
ISSN号	0040-4039
DOI	10.1016/j.tetlet.2019.151059
通讯作者	Chen, Ji-Jun(chenjj@mail.kib.ac.cn)
英文摘要	The first total synthesis of rhuscholide A, a benzofuran lactone possessing anti-HIV-1 activity, had been accomplished in 14 linear steps with 10.6% overall yield. In this synthesis, base-mediated phenol ortho-alkylation and piperidine promoted aldol condensation were exploited as key steps. The synthesis was flexible and allowed for the convenient preparation of two analogous natural products glabralide B and denudalide. (C) 2019 Published by Elsevier Ltd.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000488141200015
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/69492]
专题	中国科学院昆明植物研究所
通讯作者	Chen, Ji-Jun
作者单位	1.Chinese Acad Sci, Yunnan Key Lab Nat Med Chem, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Li, Tian-Ze,Geng, Chang-An,Chen, Ji-Jun. First total synthesis of rhuscholide A, glabralide B and denudalide[J]. TETRAHEDRON LETTERS,2019,60(38):4.
APA	Li, Tian-Ze,Geng, Chang-An,&Chen, Ji-Jun.(2019).First total synthesis of rhuscholide A, glabralide B and denudalide.TETRAHEDRON LETTERS,60(38),4.
MLA	Li, Tian-Ze,et al."First total synthesis of rhuscholide A, glabralide B and denudalide".TETRAHEDRON LETTERS 60.38(2019):4.