Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli

doi:10.1021/acs.orglett.9b02371

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli
	Chen, Yong-Hong 1,4; He, Jiang-Bo 1,2,4; Bai, Xue 3; Li, Xiao-Nian 3; Lu, Lan-Feng 1,4; Liu, Yan-Chun3 ; Zhang, Ke-Qin 1,4; Li, Sheng-Hong3 ; Niu, Xue-Mei 1,4
刊名	ORGANIC LETTERS
	2019-08-16
卷号	21 期号:16 页码:6499-6503
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02371
通讯作者	Zhang, Ke-Qin(kqzhang@ynu.edu.cn) ; Li, Sheng-Hong(shli@mail.kib.ac.cn) ; Niu, Xue-Mei(xmniu@ynu.edu.cn)
英文摘要	Here we provide an unprecedented biofactory where fluorescent dye-like complex xanthenes could be produced in an engineered Escherichia coli. Feeding the strain with toluquinol or hydroquinones resulted in production of novel "unnatural" natural products including four arthrocolins embedded with indolyltriphenyl quaternary carbons. Arthrocolins A-C potently inhibited various human cancer cell lines including paclitaxel-resistant cell line A549/Taxol and methicillin-resistant Staphylococcus aureus and immensely restored the sensitivity of intractable fluconazole-resistant human pathogen Candida albicans to fluconazole.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000481979100068
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/69456]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhang, Ke-Qin; Li, Sheng-Hong; Niu, Xue-Mei
作者单位	1.Yunnan Univ, Sch Life Sci, Minist Educ, State Key Lab Conservat & Utilizat Bioresources, Kunming 650091, Yunnan, Peoples R China 2.Kunming Univ, Kunming Key Lab Resp Dis, Kunming 650214, Yunnan, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Yunnan Univ, Key Lab Microbial Resources, Minist Educ, Sch Life Sci, Kunming 650091, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Chen, Yong-Hong,He, Jiang-Bo,Bai, Xue,et al. Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli[J]. ORGANIC LETTERS,2019,21(16):6499-6503.
APA	Chen, Yong-Hong.,He, Jiang-Bo.,Bai, Xue.,Li, Xiao-Nian.,Lu, Lan-Feng.,...&Niu, Xue-Mei.(2019).Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli.ORGANIC LETTERS,21(16),6499-6503.
MLA	Chen, Yong-Hong,et al."Unexpected Biosynthesis of Fluorescein-Like Arthrocolins against Resistant Strains in an Engineered Escherichia coli".ORGANIC LETTERS 21.16(2019):6499-6503.