Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina | |
Yu, Yang2,3; Bao, Mei-Fen2,3; Wu, Jing2,3; Chen, Jing2,3; Yang, Yu-Rong2,4; Schinnerl, Johann1; Cai, Xiang-Hai2,4 | |
刊名 | ORGANIC LETTERS |
2019-08-02 | |
卷号 | 21期号:15页码:5938-5942 |
ISSN号 | 1523-7060 |
DOI | 10.1021/acs.orglett.9b02060 |
通讯作者 | Cai, Xiang-Hai(xhcai@mail.kib.ac.cn) |
英文摘要 | Three monoterpenoid indole alkaloids (MIAs), tabernabovines A-C (1-3), were isolated from Tabernaemontana bovina. They were elucidated by spectroscopic data and computational calculations. Unlike precursors of MIAs, strictosidine and alstrostine A, alkaloid 1 consists of tryptamine and secologanin in a 2:1 ratio. Alkaloid 2 is a cage compound, and 3 possesses a bridged ring. Tabernabovine A exhibited inhibitory activity against NO production with IC50 44.1 mu M compared to L-NMMA with IC50 of 48.6 mu M. |
WOS研究方向 | Chemistry |
语种 | 英语 |
WOS记录号 | WOS:000480371600035 |
内容类型 | 期刊论文 |
源URL | [http://ir.kib.ac.cn/handle/151853/68339] |
专题 | 昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室 |
通讯作者 | Cai, Xiang-Hai |
作者单位 | 1.Univ Vienna, Div Systemat & Evolutionary Bot, Chemodivers Res Grp, Rennweg 14, A-1030 Vienna, Austria 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Yunnan Key Lab Nat Med Chem, Kunming 650201, Yunnan, Peoples R China |
推荐引用方式 GB/T 7714 | Yu, Yang,Bao, Mei-Fen,Wu, Jing,et al. Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina[J]. ORGANIC LETTERS,2019,21(15):5938-5942. |
APA | Yu, Yang.,Bao, Mei-Fen.,Wu, Jing.,Chen, Jing.,Yang, Yu-Rong.,...&Cai, Xiang-Hai.(2019).Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina.ORGANIC LETTERS,21(15),5938-5942. |
MLA | Yu, Yang,et al."Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina".ORGANIC LETTERS 21.15(2019):5938-5942. |
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