Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae

doi:10.1016/j.phytochem.2019.05.018

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae
	Chen, Keliang 1; Chen, Chunmei 1; Guo, Jieru 1,2; Sun, Weiguang 1; Liu, Junjun 1; Yang, Jing3 ; Liu, Xiulan 2; Wang, Jianping 1; Luo, Zengwei 1; Zhu, Hucheng 1
刊名	PHYTOCHEMISTRY
	2019-08-01
卷号	164 页码:236-242
关键词	Guignardia mangiferae Spirocyclic meroterpenoids Anti-inflammatory Nuclear factor-kappa B (NF-kappa B)
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.05.018
通讯作者	Zhu, Hucheng(zhuhucheng@hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn)
英文摘要	Mangiterpenes A-C and 2',3'-seco-manginoid C, four undescribed sesquiterpene/monoterpene-shikimate-conjugated meroterpenoids with spiro ring systems, were isolated from Guignardia mangiferae. The structures and absolute configurations of these compounds were established by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. Mangiterpenes A-C represent the first examples of sesquiterpene-shikimate-conjugated spirocyclic meroterpenoids, and 2',3'-seco-manginoid C features an unexpected 2',3'-seco-manginoids skeleton. Mangiterpene C strongly inhibited the production of NO inducted by LPS, with an IC50 value of 5.97 mu M. It showed an anti-inflammatory effect by means of blocking in the NF-kappa B signaling pathway and decreasing the expression of inflammatory mediators.
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
语种	英语
WOS记录号	WOS:000475996800027
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/68226]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Zhu, Hucheng; Zhang, Yonghui
作者单位	1.Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Hubei, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Chen, Keliang,Chen, Chunmei,Guo, Jieru,et al. Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae[J]. PHYTOCHEMISTRY,2019,164:236-242.
APA	Chen, Keliang.,Chen, Chunmei.,Guo, Jieru.,Sun, Weiguang.,Liu, Junjun.,...&Zhang, Yonghui.(2019).Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae.PHYTOCHEMISTRY,164,236-242.
MLA	Chen, Keliang,et al."Mangiterpenes A-C and 2 ',3 '-seco-manginoid C, four sesquiterpene/monoterpene-shikimate-conjugated spirocyclic meroterpenoids from Guignardia mangiferae".PHYTOCHEMISTRY 164(2019):236-242.