Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster

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	Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster
	Hargreaves AD 1; Zhou L 2; Li F 2; Jansen PG 3; Spiga E 5; Hansen MT 3; Mulley JF 7; Zhang GJ2,8,9; Christensen J 3; Heller RC3
刊名	Proceedings of the National Academy of Sciences of the United of America
	2017
卷号	期号:页码:Epub ahead of print
关键词	Pdx1 Desert Rodent Gene Conversion Homeobox Type 2 Diabetes
英文摘要	The sand rat Psammomys obesus is a gerbil species native to deserts of North Africa and the Middle East, and is constrained in its ecology because high carbohydrate diets induce obesity and type II diabetes that, in extreme cases, can lead to pancreatic failure and death. We report the sequencing of the sand rat genome and discovery of an unusual, extensive, and mutationally biased GC-rich genomic domain. This highly divergent genomic region encompasses several functionally essential genes, and spans the ParaHox cluster which includes the insulin-regulating homeobox gene Pdx1. The sequence of sand rat Pdx1 has been grossly affected by GC-biased mutation, leading to the highest divergence observed for this gene across the Bilateria. In addition to genomic insights into restricted caloric intake in a desert species, the discovery of a localized chromosomal region subject to elevated mutation suggests that mutational heterogeneity within genomes could influence the course of evolution.
语种	英语
资助机构	This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179. ; This work was funded principally by the European Research Council under European Union’s Seventh Framework Programme (FP7/2007- 2013 ERC Grant 268513 to P.W.H.H.), a Strategic Priority Research Program of the Chinese Academy of Sciences Grant XDB13000000 (to G.Z.), and Novo Nordisk A/S (coordinated by R.S.H.). E.S. and W.R.T. were supported by the Francis Crick Institute under award FC001179.
内容类型	期刊论文
源URL	[http://159.226.149.26:8080/handle/152453/11789]
专题	昆明动物研究所_遗传资源与进化国家重点实验室昆明动物研究所_基因起源组
通讯作者	peter.holland@zoo.ox.ac.uk, zhanggj@genomics.cn,richardscottheller@gmail.com.
作者单位	1.Department of Zoology, University of Oxford, Oxford, OX1 3PS, United Kingdom 2.China National Genebank, BGI-Shenzhen, 518083, Shenzhen, Guangdong, China 3.Novo Nordisk, Måløv, DK-2760, Denmark 4.Molecular Genetics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa 904-0495, Japan 5.Francis Crick Institute, London, NW1 1AT, United Kingdom 6.Novo Nordisk Research Centre, Seattle, WA 98109; g School of Biological Sciences, Bangor University, Bangor, LL57 2DG, United Kingdom 7.School of Biological Sciences, Bangor University, Bangor, LL57 2DG, United Kingdom 8.State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, 650223, Kunming, China 9.Centre for Social Evolution, Department of Biology, University of Copenhagen, DK-2100 Copenhagen, Denmark
推荐引用方式 GB/T 7714	Hargreaves AD,Zhou L,Li F,et al. Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster[J]. Proceedings of the National Academy of Sciences of the United of America,2017,():Epub ahead of print.
APA	Hargreaves AD.,Zhou L.,Li F.,Jansen PG.,Spiga E.,...&peter.holland@zoo.ox.ac.uk, zhanggj@genomics.cn,richardscottheller@gmail.com..(2017).Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster.Proceedings of the National Academy of Sciences of the United of America,(),Epub ahead of print.
MLA	Hargreaves AD,et al."Genome sequence of a diabetes-prone rodent reveals a mutation hotspot around the ParaHox gene cluster".Proceedings of the National Academy of Sciences of the United of America .(2017):Epub ahead of print.