Plasma lipidomic signatures of spontaneous obese rhesus monkeys

CORC > 昆明动物研究所 > 昆明动物研究所 > 动物模型与人类重大疾病机理重点实验室 > 脂类代谢与疾病

	Plasma lipidomic signatures of spontaneous obese rhesus monkeys
	Wang, JL; Zhang, LQ; Xiao, RY; Li, YH; Liao, SS; Zhang, ZG; Yang, WH; Liang, B
刊名	LIPIDS IN HEALTH AND DISEASE
	2019
卷号	18
ISSN号	1476-511X
英文摘要	BackgroundObesity plays crucial roles in the pathogenesis of metabolic diseases such as hyperlipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes (T2D). The underlying mechanisms linking obesity to metabolic diseases are still less understandable.MethodsPreviously, we screened a group of spontaneously obese rhesus monkeys. Here, we performed a plasma lipidomic analysis of normal and obese monkeys using gas chromatography/mass spectroscopy (GC/MS) and ultra-high performance liquid chromatography/mass spectroscopy (UPLC/MS).ResultsIn total, 143 lipid species were identified, quantified, and classified into free fatty acids (FFA), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), phosphatidylglycerol (PG), lysophosphatidylcholine (LPC), lysophosphatidic acid (LPA), and sphingomyelin (SM). Data analysis showed that the obese monkeys had increased levels of fatty acids palmitoleic acid (C16:1) and arachidonic acid (C20:4), FFA especially palmitic acid (C16:0), as well as certain PC species and SM species. Surprisingly, the plasma level of LPA-C16:0 was approximately four-fold greater in the obese monkeys. Conversely, the levels of most PE species were obviously reduced in the obese monkeys.ConclusionCollectively, our work suggests that lipids such as FFA C16:0 and 16:0-LPA may be potential candidates for the diagnosis and study of obesity-related diseases.
语种	英语
内容类型	期刊论文
源URL	[http://ir.kiz.ac.cn:8080/handle/152453/12531]
专题	昆明动物研究所_脂类代谢与疾病
推荐引用方式 GB/T 7714	Wang, JL,Zhang, LQ,Xiao, RY,et al. Plasma lipidomic signatures of spontaneous obese rhesus monkeys[J]. LIPIDS IN HEALTH AND DISEASE,2019,18.
APA	Wang, JL.,Zhang, LQ.,Xiao, RY.,Li, YH.,Liao, SS.,...&Liang, B.(2019).Plasma lipidomic signatures of spontaneous obese rhesus monkeys.LIPIDS IN HEALTH AND DISEASE,18.
MLA	Wang, JL,et al."Plasma lipidomic signatures of spontaneous obese rhesus monkeys".LIPIDS IN HEALTH AND DISEASE 18(2019).