(+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1

doi:10.1021/acs.orglett.9b00475

	(+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1
	Wu, JC ; Hou, YA ; Xu, QH ; Jin, XJ ; Chen, YX ; Fang, JG ; Hu, BR; Wu, QX
刊名	ORGANIC LETTERS
	2019
卷号	21 期号:5 页码:1551-1554
DOI	10.1021/acs.orglett.9b00475
英文摘要	A pair of enantiomeric polyketides, (+)- and (-)-alternamgin (1), featuring an unprecedented 6/6/6/6/5/6/6 seven ring backbone, were isolated from the endophytic fungi Alternaria sp. MG1. The relative configuration of 1 was determined using X-ray diffraction, and the absolute configurations of (+/-)-1 were confirmed by comparing the experimental and calculated ECD data. Plausible biosynthetic pathways for 1 were proposed. Compound (-)-I exhibited moderate necrosis rates to Hela and HepG2 cells, but (+)-1 only showed similar necrosis rates to HepG2 cells.
WOS记录号	WOS:000460491700067
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/136008]
专题	中国科学院近代物理研究所
通讯作者	Wu, QX
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Key Lab Heavy Ion Radiat Biol & Med, Lanzhou 730000, Gansu, Peoples R China 2.Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China 3.Gansu Univ Chinese Med, Coll Pharm, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Wu, JC,Hou, YA,Xu, QH,et al. (+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1[J]. ORGANIC LETTERS,2019,21(5):1551-1554.
APA	Wu, JC.,Hou, YA.,Xu, QH.,Jin, XJ.,Chen, YX.,...&Wu, QX.(2019).(+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1.ORGANIC LETTERS,21(5),1551-1554.
MLA	Wu, JC,et al."(+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1".ORGANIC LETTERS 21.5(2019):1551-1554.