"Saddle-shaped" dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?

doi:10.1007/s13213-019-1442-7

	"Saddle-shaped" dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?
	Guo, Xiaopeng 1,2; Zhang, Miaomiao1,2,3 ; Gao, Yue 1,2; Li, Wenjian1,3 ; Lu, Dong1,3
刊名	ANNALS OF MICROBIOLOGY
	2019-03-01
卷号	69 期号:3 页码:221-232
关键词	Bibliometric analysis Heavy ion beam irradiation Microbial mutation breeding "Saddle-shaped" survival curve Positive mutation rate
ISSN号	1590-4261
DOI	10.1007/s13213-019-1442-7
英文摘要	We aimed to verify the saddle-shaped dose-survival effect of microbes in response to heavy ion beam irradiation (HI), and further determine the radiation parameter that affects saddle shape formation, and the relationship between the saddle region and the positive mutation rate. A bibliometric analysis was performed based on literature containing the dose-survival effect of microbes in response to HI, from which the data on the particle energies, ionic types, irradiated microbes, survival curves, and maximum positive mutation rates were assembled. Articles reporting a saddle-shaped survival curve accounted for 64% of the total relevant articles and possessed a high cited frequency. The predominant articles, authors, and institutions that reported the dose-survival effect of microbes in response to HI proposed the saddle-shaped survival curve. It was customarily low-energy (but not moderate- or high-energy) HI that induced the saddle-shaped dose-survival effect. In addition, the saddle-shaped dose-survival effect was general among 30-genera microbes. More importantly, most of the saddle regions contained the survival fractions within 10-30%, which are customarily used to screen mutants due to a high positive mutation rate. Further, 87% of the maximum positive mutation rates were associated with the saddle region, and 58% were located in the peak of the saddle region. Saddle-shaped dose-survival effect is a reliable and general phenomenon among varieties of microbes customarily in response to low-energy HI. Meanwhile, saddle region is always accompanied with high positive mutation rates. Thus, this study will aid in microbial mutation breeding practices.
资助项目	Chinese Academy of Sciences Key Deployment Project[KFZD-SW-109] ; Chinese Academy of Sciences[CAS-ITRI 201801] ; National Natural Science Fund of China[11575259] ; Industrial Technology Research Institute[CAS-ITRI 201801]
WOS关键词	GLUCONOBACTER-OXYDANS ; BACILLUS-SUBTILIS ; ACID PRODUCTION ; MUTANT STRAIN ; IMPLANTATION ; ENHANCEMENT ; MUTATION ; FERMENTATION ; MUTAGENESIS ; IMPROVEMENT
WOS研究方向	Biotechnology & Applied Microbiology ; Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000461398600004
资助机构	Chinese Academy of Sciences Key Deployment Project ; Chinese Academy of Sciences ; National Natural Science Fund of China ; Industrial Technology Research Institute
内容类型	期刊论文
源URL	[http://119.78.100.186/handle/113462/134071]
专题	中国科学院近代物理研究所
通讯作者	Lu, Dong
作者单位	1.Chinese Acad Sci, Inst Modern Phys, Lanzhou 730000, Gansu, Peoples R China 2.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 3.Gansu Key Lab Microbial Resources Exploitat & App, Lanzhou 730000, Gansu, Peoples R China
推荐引用方式 GB/T 7714	Guo, Xiaopeng,Zhang, Miaomiao,Gao, Yue,et al. "Saddle-shaped" dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?[J]. ANNALS OF MICROBIOLOGY,2019,69(3):221-232.
APA	Guo, Xiaopeng,Zhang, Miaomiao,Gao, Yue,Li, Wenjian,&Lu, Dong.(2019)."Saddle-shaped" dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?.ANNALS OF MICROBIOLOGY,69(3),221-232.
MLA	Guo, Xiaopeng,et al.""Saddle-shaped" dose-survival effect, is it a general and valuable phenomenon in microbes in response to heavy ion beam irradiation?".ANNALS OF MICROBIOLOGY 69.3(2019):221-232.