Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications

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	Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
	LIAO RIJING ; DUAN LIAN ; LEI CHUN ; PAN HAIXUE ; DING YING ; Zhang Q(张琪) ; CHEN DAIJIE ; SHEN BEN ; Yu Y(虞沂) ; Liu W(刘文)
刊名	Chem. Biol.
	2009
卷号	16 期号:2 页码:141-147
ISSN号	1074-5521
其他题名	Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications
通讯作者	虞沂 ; 刘文
英文摘要	Thiopeptides, with potent activity against various drug-resistant pathogens, contain a characteristic macrocyclic core consisting of multiple thiazoles, dehydroamino acids, and a 6-membered nitrogen heterocycle. Their biosynthetic pathways remain elusive, in spite of great efforts by in vivo feeding experiments. Here, cloning, sequencing, and characterization of the thiostrepton and siomycin A gene clusters unveiled a biosynthetic paradigm for the thiopeptide specific core formation, featuring ribosomally synthesized precursor peptides and conserved posttranslational modifications. The paradigm generality for thiopeptide biosynthesis was supported by genome mining and ultimate confirmation of the thiocillin I production in Bacillus cereus ATCC 14579, a strain that was previously unknown as a thiopeptide producer. These findings set the stage to accelerate the discovery of thiopeptides by prediction at the genetic level and to generate structural diversity by applying combinatorial biosynthesis methods.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.chembiol.2009.01.007
语种	英语
WOS记录号	WOS:000263852700006
公开日期	2013-08-23
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/28453]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	LIAO RIJING,DUAN LIAN,LEI CHUN,et al. Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications[J]. Chem. Biol.,2009,16(2):141-147.
APA	LIAO RIJING.,DUAN LIAN.,LEI CHUN.,PAN HAIXUE.,DING YING.,...&刘文.(2009).Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications.Chem. Biol.,16(2),141-147.
MLA	LIAO RIJING,et al."Thiopeptide Biosynthesis Featuring Ribosomally Synthesized Precursor Peptides and Conserved Posttranslational Modifications".Chem. Biol. 16.2(2009):141-147.