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	Upregulation of KIF20A correlates with poor prognosis in gastric cancer
	Sheng, Yi1; Wang, Wei2; Hong, Bo2; Jiang, Xingwang1; Sun, Ruochuan1; Yan, Qiang1; Zhang, Shangxin1; Lu, Mingdian1; Wang, Shengyi1; Zhang, Zhen1
刊名	CANCER MANAGEMENT AND RESEARCH
	2018
卷号	10页码:6205-6216
关键词	KIF20A genistein gastric cancer prognosis
ISSN号	1179-1322
DOI	10.2147/CMAR.S176147
通讯作者	Lin, Wenchu(wenchu@hmfl.ac.cn) ; Li, Yongxiang(yongxiangli_1@hotmail.com)
英文摘要	Badcground: KIF20A is well known as one of the key proteins in mitosis. Recently, a number of studies illustrated that KIF20A might function as an oncogene in some carcinomas. However, its expression levels and clinical value remained unclear in gastric cancer (GC). Patients and methods: In this study, we investigated the expression of KIF20A in samples from GC patients and cell lines by quantitative real-time PCR and Western blot. The function of KIF20A in cell proliferation of GC cell lines was examined via cell viability and colony formation assays. Immunohistochemistry assay based on a tissue microarray consisting of 146 cases was performed to evaluate the prognostic value of KIF20A. The overall survival rate of 122 GC patients based on KIF20A expression was analyzed as well. Finally, using KIF20A inhibitor, genistein, and combining it with cisplatin or fluorouracil, the antitumor effects were studied. Results: Most GC samples (56.76%) showed higher KIF20A expression level compared to their corresponding normal specimens, which demonstrated the potential oncogenic role of KIF2OA in GC. The functional studies elucidated the essential role of KIF20A in GC cell proliferation. Besides, tissue microarray result showed that the expression level of KIF20A was significantly related to the histological grades (P=0.036). Furthermore, we found the expression of KIF20A was related to poor overall survival rate, which is coincident with the results from Kaplan-Meier plotter database. In addition, we found that a KIF20A inhibitor, genistein, could enhance the antitumor activity of cisplatin and fluorouracil, which might be considered as a chemosensitive agent in GC. Conclusion: KIF20A can promote cell proliferation in GC, which might be used as an independent prognostic factor and a potential therapeutic target.
资助项目	National Natural Science Foundation of China[81672389] ; National Natural Science Foundation of China[81672647] ; National Natural Science Foundation of China[81702954] ; National Natural Science Foundation of China[81372214] ; Key Science and Technology Program of Anhui Province[1704a0802167] ; Natural Science Research Project of Anhui Province[KJ2016A329] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences[KFJ-STS-SCYD-010] ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology[2016FXCX006] ; Key Technologies R&D Programme of Anhui Province[1604a0802103] ; 100-Talent Program of Chinese Academy of Sciences
WOS关键词	CHROMOSOMAL PASSENGERS ; DOWN-REGULATION ; CENTRAL SPINDLE ; TUMOR-GROWTH ; AURORA-B ; KINESIN ; GENISTEIN ; EXPRESSION ; PROTEIN ; 5-FLUOROURACIL
WOS研究方向	Oncology
语种	英语
出版者	DOVE MEDICAL PRESS LTD
WOS记录号	WOS:000451786700002
资助机构	National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Key Science and Technology Program of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Natural Science Research Project of Anhui Province ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Science and Technology Service Network Initiative of Chinese Academy of Sciences ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Major/Innovative Program of Development Foundation of Hefei Center for Physical Science and Technology ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; Key Technologies R&D Programme of Anhui Province ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences ; 100-Talent Program of Chinese Academy of Sciences
内容类型	期刊论文
源URL	[http://ir.hfcas.ac.cn:8080/handle/334002/40329]
专题	合肥物质科学研究院_中科院强磁场科学中心
通讯作者	Lin, Wenchu; Li, Yongxiang
作者单位	1.Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, 218 Jixi Rd, Hefei 230022, Anhui, Peoples R China 2.Chinese Acad Sci, High Magnet Field Lab, 350 Shushanhu Rd, Hefei 230031, Anhui, Peoples R China
推荐引用方式 GB/T 7714	Sheng, Yi,Wang, Wei,Hong, Bo,et al. Upregulation of KIF20A correlates with poor prognosis in gastric cancer[J]. CANCER MANAGEMENT AND RESEARCH,2018,10:6205-6216.
APA	Sheng, Yi.,Wang, Wei.,Hong, Bo.,Jiang, Xingwang.,Sun, Ruochuan.,...&Li, Yongxiang.(2018).Upregulation of KIF20A correlates with poor prognosis in gastric cancer.CANCER MANAGEMENT AND RESEARCH,10,6205-6216.
MLA	Sheng, Yi,et al."Upregulation of KIF20A correlates with poor prognosis in gastric cancer".CANCER MANAGEMENT AND RESEARCH 10(2018):6205-6216.

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