structuralanalysisofhighdegreepolymerizationisomersofhumanmilkoligosaccharidesbasedonelectrosprayionizationquadrupoletimeofflightmassspectrometry

	structuralanalysisofhighdegreepolymerizationisomersofhumanmilkoligosaccharidesbasedonelectrosprayionizationquadrupoletimeofflightmassspectrometry
	Li Xin; Li JiaQi; Jin GaoWa; Yu Long; Guo ZhiMou; Liang XinMiao; Liu Shuai; Yan JingYu
刊名	chinesejournalofanalyticalchemistry
	2019-01-01
卷号	47 期号:7 页码:1106
ISSN号	0253-3820
英文摘要	Human milk oligosaccharides are a kind of natural prebiotics that exist in human milk. They play an irreplaceable role in the growth of infantile intestinal flora, the improvement of immune system and the resistance to pathogen infection. The function of human milk oligosaccharides is closely related to their structures which are complex with various linkages. Besides , the oligosaccharides have a large number of isomers , the number and complexity of which increase dramatically with the degrees of their polymerization. Therefore , the structural analysis of oligosaccharide isomers with a high degree of polymerization is one of the difficulties in the study of human milk oligosaccharides , and is of great significance for the study of the biological function of oligosaccharides. In this study , electrospray ionization-quadrupole-time of flight mass spectrometry ( ESI-Q/TOF-MS ) was used to analyze the structures of eighteen high-degree polymerized human milk oligosaccharides in a negative ion mode , and three of them were firstly reported. Differences of fragment ions between the isomers were discussed, and the cleavage rules of oligosaccharide isomers were summarized. This study provided a scientific basis for the structural analysis of the complex isomers of highly polymerized human milk oligosaccharides and the discovery of novel sugar structures.
资助项目	[National Key Research and Development Program of China] ; [National Natural Science Foundation of China]
语种	英语
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/174543]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
作者单位	中国科学院大连化学物理研究所
推荐引用方式 GB/T 7714	Li Xin,Li JiaQi,Jin GaoWa,et al. structuralanalysisofhighdegreepolymerizationisomersofhumanmilkoligosaccharidesbasedonelectrosprayionizationquadrupoletimeofflightmassspectrometry[J]. chinesejournalofanalyticalchemistry,2019,47(7):1106.
APA	Li Xin.,Li JiaQi.,Jin GaoWa.,Yu Long.,Guo ZhiMou.,...&Yan JingYu.(2019).structuralanalysisofhighdegreepolymerizationisomersofhumanmilkoligosaccharidesbasedonelectrosprayionizationquadrupoletimeofflightmassspectrometry.chinesejournalofanalyticalchemistry,47(7),1106.
MLA	Li Xin,et al."structuralanalysisofhighdegreepolymerizationisomersofhumanmilkoligosaccharidesbasedonelectrosprayionizationquadrupoletimeofflightmassspectrometry".chinesejournalofanalyticalchemistry 47.7(2019):1106.