Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures

doi:10.1021/acs.analchem.9b01700

	Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures
	Chen, Hong 1,2; Chen, Chuang 2; Huang, Wei 2; Li, Mei 1,2; Xiao, Yao 1,2; Jiang, Dandan 2; Li, Haiyang 2
刊名	ANALYTICAL CHEMISTRY
	2019-07-16
卷号	91 期号:14 页码:9138-9146
ISSN号	0003-2700
DOI	10.1021/acs.analchem.9b01700
通讯作者	Chen, Chuang(chenchuang@dicp.ac.cn) ; Li, Haiyang(hli@dicp.ac.cn)
英文摘要	The hidden presence of fentanyl and new psychoactive substances in established illicit drugs has led to a great number of unintentional fatal overdoses, justifying the urgent need for portable tools for the rapid screening of various drugs. Ion mobility spectrometry, as a rapid detection technique, has been widely used in detecting illicit drugs, whereas it is insufficiently sensitive for bigger ions due to the mobility discrimination of an ion shutter. In this work, a miniaturized ion mobility spectrometer with an inner diameter of 14 mm and a drift length of 38.9 mm and equipped with a novel dual-compression tristate ion shutter has been developed, which could greatly reduce the mobility discrimination by compressing the ion packet twice during the injection process. The best gating performance of the dual-compression tristate ion shutter was about three times as high as that of the tristate ion shutter and twice as high as that of the Tyndall-Powell shutter. For example, the peak height was increased by 150 or 40% when the resolving power was the same, whereas the resolution of two neighboring peaks was improved by 46 or 19% when the peak heights were the same. In screening of fentanyl drug mixtures, the new shutter enhanced the identification accuracy of constituents by making peaks of slow dimer ions and complex ions observable. Besides, the new shutter helped to achieve high sensitivity for drug ions spreading a wide ion mobility range from 0.644 to 2.032 cm(2) s(-1) V-1, demonstrating its potential use in the analysis of other mixtures and the detection of large ions.
资助项目	National Key R&D Program of China[2016YFC0201200] ; National Key R&D Program of China[2016YFC0800912] ; National Natural Science Foundation of China[21405158] ; National Natural Science Foundation of China[21707138] ; Dalian Institute of Chemical Physics[DICP ZZBS201709] ; Dalian Institute of Chemical Physics[DICP ZZBS201801] ; Dalian Institute of Chemical Physics[DICPZZBS201808] ; Scientific Study Project of Liaoning Province Educational Commission of China[LQ201715001]
WOS关键词	THERMAL-DESORPTION ; COCAINE ; MS ; TRANSMISSION ; OPIATES ; COMPLEX ; URINE ; ABUSE
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000476567700055
资助机构	National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Dalian Institute of Chemical Physics ; Dalian Institute of Chemical Physics ; Scientific Study Project of Liaoning Province Educational Commission of China ; Scientific Study Project of Liaoning Province Educational Commission of China
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/173981]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Chen, Chuang; Li, Haiyang
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, Key Lab Separat Sci Analyt Chem, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Chen, Hong,Chen, Chuang,Huang, Wei,et al. Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures[J]. ANALYTICAL CHEMISTRY,2019,91(14):9138-9146.
APA	Chen, Hong.,Chen, Chuang.,Huang, Wei.,Li, Mei.,Xiao, Yao.,...&Li, Haiyang.(2019).Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures.ANALYTICAL CHEMISTRY,91(14),9138-9146.
MLA	Chen, Hong,et al."Miniaturized Ion Mobility Spectrometer with a Dual-Compression Tristate Ion Shutter for On-Site Rapid Screening of Fentanyl Drug Mixtures".ANALYTICAL CHEMISTRY 91.14(2019):9138-9146.