Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies

doi:10.1002/adma.201902048

	Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies
	Yang, Kaiguang 2; Li, Senwu 2; Liu, Lukuan 2; Chen, Yuwan 2; Zhou, Wen 2; Pei, Jiaqi 1,2; Liang, Zhen 2; Zhang, Lihua 2; Zhang, Yukui 2
刊名	ADVANCED MATERIALS
	2019-08-18
页码	17
关键词	artificial antibodies epitopes molecular imprinting molecular recognition
ISSN号	0935-9648
DOI	10.1002/adma.201902048
通讯作者	Zhang, Lihua(lihuazhang@dicp.ac.cn)
英文摘要	Epitope imprinting is a promising tool to generate antibody-like specific recognition sites. Recently, because of the ease of obtaining templates, the flexibility in selecting monomers, their resistance to harsh environments, and the high specificity toward targets, epitope-imprinted materials have attracted much attention in various fields, such as bioanalysis, clinical therapy, and pharmacy. Here, the discussion is focused on the current representative epitope imprinting technologies, including epitope bulk imprinting and epitope surface imprinting. Moreover, the application of epitope-imprinted materials to the recognition of peptides, proteins, and cells is reviewed. Finally, the remaining challenges arising from the intrinsic properties of epitope imprinting are discussed, and future development in the field is prospected.
资助项目	National Key R&D Programme of China[2017YFA0505003] ; National Natural Science Foundation[21575143] ; National Natural Science Foundation[21725506] ; CAS Key Project in Frontier Science[QYZDY-SSW-SLH017] ; Innovation Programme of Science and Research from the DICP, CAS[DICP TMSR201601]
WOS关键词	PROTEIN LYSINE ACETYLATION ; MASS-SPECTROMETRY ; IMMUNOGLOBULIN-G ; CANCER-CELLS ; HUMAN SERUM ; POLYMERS ; RECOGNITION ; AFFINITY ; NANOPARTICLES ; PURIFICATION
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000481819300001
资助机构	National Key R&D Programme of China ; National Key R&D Programme of China ; National Natural Science Foundation ; National Natural Science Foundation ; CAS Key Project in Frontier Science ; CAS Key Project in Frontier Science ; Innovation Programme of Science and Research from the DICP, CAS ; Innovation Programme of Science and Research from the DICP, CAS ; National Key R&D Programme of China ; National Key R&D Programme of China ; National Natural Science Foundation ; National Natural Science Foundation ; CAS Key Project in Frontier Science ; CAS Key Project in Frontier Science ; Innovation Programme of Science and Research from the DICP, CAS ; Innovation Programme of Science and Research from the DICP, CAS ; National Key R&D Programme of China ; National Key R&D Programme of China ; National Natural Science Foundation ; National Natural Science Foundation ; CAS Key Project in Frontier Science ; CAS Key Project in Frontier Science ; Innovation Programme of Science and Research from the DICP, CAS ; Innovation Programme of Science and Research from the DICP, CAS ; National Key R&D Programme of China ; National Key R&D Programme of China ; National Natural Science Foundation ; National Natural Science Foundation ; CAS Key Project in Frontier Science ; CAS Key Project in Frontier Science ; Innovation Programme of Science and Research from the DICP, CAS ; Innovation Programme of Science and Research from the DICP, CAS
内容类型	期刊论文
源URL	[http://cas-ir.dicp.ac.cn/handle/321008/173531]
专题	大连化学物理研究所_中国科学院大连化学物理研究所
通讯作者	Zhang, Lihua
作者单位	1.Dalian Univ Technol, Zhang Dayu Sch Chem, Dalian 116024, Peoples R China 2.Chinese Acad Sci, CAS Key Lab Separat Sci Analyt Chem, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
推荐引用方式 GB/T 7714	Yang, Kaiguang,Li, Senwu,Liu, Lukuan,et al. Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies[J]. ADVANCED MATERIALS,2019:17.
APA	Yang, Kaiguang.,Li, Senwu.,Liu, Lukuan.,Chen, Yuwan.,Zhou, Wen.,...&Zhang, Yukui.(2019).Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies.ADVANCED MATERIALS,17.
MLA	Yang, Kaiguang,et al."Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies".ADVANCED MATERIALS (2019):17.