YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin

	YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin
	Cheng ZY ; Ma PA ; Hou ZY ; Wang WX ; Dai YL ; Zhai XF ; Lin J
刊名	dalton transactions
	2012
卷号	41 期号:5 页码:1481-1489
关键词	ORDERED MESOPOROUS MATERIALS UP-CONVERSION-LUMINESCENT DRUG-DELIVERY NANOPARTICLES OXIDE SYSTEMS SHELL SIZE PHOTOLUMINESCENCE NANOPHOSPHORS
ISSN号	1477-9226
通讯作者	lin j
中文摘要	porous silica microspheres were fabricated by a facile surface-protected etching strategy. polyvinylpyrrolidone (pvp) was used as a protecting polymer absorbed on the surface of silica microspheres and naoh was employed as an etching agent. owing to the protective action of pvp and inhomogeneous etching, mesopores were created in the silica microspheres. then, based on the pechini-type sol-gel and impregnating process, yvo4:eu3+ nanocrystals were integrated into the channels to form highly luminescent yvo4:eu3+@sio2 composite microspheres. the biocompatibility tests on l929 fibroblast cells using mtt assay reveal low cytotoxicity of the system. owing to the large interior space and electrostatic interaction, the porous microspheres show a relatively high loading capacity (438 mg dox/yvo4:eu3+@sio2 g) and encapsulation efficiency (87.6%) for the anti-cancer drug doxorubicin hydrochloride (dox). the drug release behavior and cytotoxic effect against human cervical carcinoma cells (hela cells) of the dox-loaded yvo4:eu3+@sio2 carriers were investigated in vitro. it was found that the carriers present a highly ph-dependent drug release behavior due to electrostatic interaction between the silica surface and dox molecules. the drug release rate became greater at low ph owing to the increased electrostatic repulsion. the dox-loaded carriers demonstrate a similar or even greater anti-cancer activity with respect to the free dox against hela cells. furthermore, the pl intensity of the microspheres shows correlation with the cumulative release of dox. these results suggest that the composite can potentially act as a multifunctional drug carrier system with luminescent tagging and ph-controlled release properties.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000299054500012
公开日期	2013-08-29
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48724]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Cheng ZY,Ma PA,Hou ZY,et al. YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin[J]. dalton transactions,2012,41(5):1481-1489.
APA	Cheng ZY.,Ma PA.,Hou ZY.,Wang WX.,Dai YL.,...&Lin J.(2012).YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin.dalton transactions,41(5),1481-1489.
MLA	Cheng ZY,et al."YVO4:Eu3+ functionalized porous silica submicrospheres as delivery carriers of doxorubicin".dalton transactions 41.5(2012):1481-1489.