Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents
	Wang, Xue-Quan 1; Liu, Lan-Xiang 1; Li, Yan2 ; Sun, Cheng-Jun 1; Chen, Wen 1; Li, Liang 1; Zhang, Hong-Bin 1; Yang, Xiao-Dong 1
刊名	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
	2013-04-01
卷号	62 页码:111-121
关键词	Hybrid compound 2-Benzylbenzofuran Imidazole Cytotoxic activities Structure-activity relationships
ISSN号	0223-5234
通讯作者	Yang, XD (reprint author), Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China. ; xdyang@ynu.edu.cn
英文摘要	A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.
学科主题	Chemistry, Medicinal
WOS标题词	Science & Technology ; Life Sciences & Biomedicine
类目[WOS]	Chemistry, Medicinal
研究领域[WOS]	Pharmacology & Pharmacy
关键词[WOS]	CYTOTOXIC ACTIVITIES ; DERIVATIVES ; ANALOGS ; DISCOVERY ; SALTS
收录类别	SCI ; IC
资助信息	National Natural Science Foundation of China [30960460, 20925205, 21062026]; Natural Science Foundation of Yunnan Province [2010GA014, 2012FB113]; National Basic Research Program of China (973 Program) [2009CB522300]
语种	英语
WOS记录号	WOS:000318577500012
公开日期	2013-07-24
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/16577]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
作者单位	1.Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xue-Quan,Liu, Lan-Xiang,Li, Yan,et al. Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2013,62:111-121.
APA	Wang, Xue-Quan.,Liu, Lan-Xiang.,Li, Yan.,Sun, Cheng-Jun.,Chen, Wen.,...&Yang, Xiao-Dong.(2013).Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,62,111-121.
MLA	Wang, Xue-Quan,et al."Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 62(2013):111-121.