Xinjiang is a multi-ethnic settlement and the ethnic minority especially Uighurs occupies a great proportion in the population of Xinxiang. In this information communion era, cultural exchange among nationalities is more and more frequent and how to use advanced information technology to complete machine translation and cross-language knowledge retrieval and other tasks has become the urgent requirement of people. Nowadays, there are many problems for these studies and one of key issues is how to choose words correctly for the polysemous words of the target language in the process of translation, which is called translation disambiguation. As a “middle task”, Uygur and Chinese translation disambiguation research is directly related to the efficiency and success or failure of language processing application systems such as machine translation and cross-language question and answer between Uygur and Chinese and it is a key basic research topic in computational linguistics.