Heterosynaptic long-term depression mediated by ATP released from astrocytes

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	Heterosynaptic long-term depression mediated by ATP released from astrocytes
	Chen, JD ; Tan, ZB ; Zeng, L ; Zhang, XX ; He, Y ; Gao, W ; Wu, XM ; Li, YJ ; Bu, BT ; Wang, W ; Duan, SM
刊名	GLIA
	2013
卷号	61 期号:2 页码:178-191
关键词	CULTURED HIPPOCAMPAL-NEURONS GLIAL-CELLS SYNAPTIC-TRANSMISSION D-SERINE GLUTAMATE RELEASE CALCIUM WAVES POTENTIATION STIMULATION PLASTICITY RECEPTOR
ISSN号	0894-1491
通讯作者	Duan, SM (reprint author), Zhejiang Univ, Sch Med, Key Lab Neurobiol Zhejiang Prov, Minist Hlth China,Dept Neurobiol,Key Lab Med Neur, Hangzhou 310003, Zhejiang, Peoples R China.,duanshumin@zju.edu.cn
英文摘要	Heterosynaptic long-term depression (hLTD) at untetanized synapses accompanying the induction of long-term potentiation (LTP) spatially sharpens the activity-induced synaptic potentiation; however, the underlying mechanism remains unclear. We found that hLTD in the hippocampal CA1 region is caused by stimulation-induced ATP release from astrocytes that suppresses transmitter release from untetanized synaptic terminals via activation of P2Y receptors. Selective stimulation of astrocytes expressing channelrhodopsin-2, a light-gated cation channel permeable to Ca2+, resulted in LTD of synapses on neighboring neurons. This synaptic modification required Ca2+ elevation in astrocytes and activation of P2Y receptors, but not N-methyl-D-aspartate receptors. Furthermore, blocking P2Y receptors or buffering astrocyte intracellular Ca2+ at a low level prevented hLTD without affecting LTP induced by SC stimulation. Thus, astrocyte activation is both necessary and sufficient for mediating hLTD accompanying LTP induction, strongly supporting the notion that astrocytes actively participate in activity-dependent synaptic plasticity of neural circuits. (c) 2012 Wiley Periodicals, Inc.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	Major State Basic Research Program of China [2011CB504400, 2011CBA00400]; National Natural Science Foundation of China [30730037, 31190060]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2517]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Chen, JD,Tan, ZB,Zeng, L,et al. Heterosynaptic long-term depression mediated by ATP released from astrocytes[J]. GLIA,2013,61(2):178-191.
APA	Chen, JD.,Tan, ZB.,Zeng, L.,Zhang, XX.,He, Y.,...&Duan, SM.(2013).Heterosynaptic long-term depression mediated by ATP released from astrocytes.GLIA,61(2),178-191.
MLA	Chen, JD,et al."Heterosynaptic long-term depression mediated by ATP released from astrocytes".GLIA 61.2(2013):178-191.