Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish

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	Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish
	Du, JL
刊名	PLOS COMPUTATIONAL BIOLOGY
	2013
卷号	9 期号:2 页码:-e1002940
关键词	TRANSCRIPTION FACTOR CLOCK EXPRESSION LIGHT REVEALS NEUROSPORA PATHWAYS CELLS MOUSE CRX
ISSN号	1553-7358
通讯作者	Yan, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, CAS MPG Partner Inst Computat Biol, Shanghai, Peoples R China.,junyan@picb.ac.cn
英文摘要	In the study of circadian rhythms, it has been a puzzle how a limited number of circadian clock genes can control diverse aspects of physiology. Here we investigate circadian gene expression genome-wide using larval zebrafish as a model system. We made use of a spatial gene expression atlas to investigate the expression of circadian genes in various tissues and cell types. Comparison of genome-wide circadian gene expression data between zebrafish and mouse revealed a nearly anti-phase relationship and allowed us to detect novel evolutionarily conserved circadian genes in vertebrates. We identified three groups of zebrafish genes with distinct responses to light entrainment: fast light-induced genes, slow light-induced genes, and dark-induced genes. Our computational analysis of the circadian gene regulatory network revealed several transcription factors (TFs) involved in diverse aspects of circadian physiology through transcriptional cascade. Of these, microphthalmia-associated transcription factor a (mitfa), a dark-induced TF, mediates a circadian rhythm of melanin synthesis, which may be involved in zebrafish's adaptation to daily light cycling. Our study describes a systematic method to discover previously unidentified TFs involved in circadian physiology in complex organisms.
学科主题	Biochemistry & Molecular Biology ; Mathematical & Computational Biology
收录类别	SCI
资助信息	SIBS; Chinese Academy of Sciences; German Max-Planck Society
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2515]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Du, JL. Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish[J]. PLOS COMPUTATIONAL BIOLOGY,2013,9(2):-e1002940.
APA	Du, JL.(2013).Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish.PLOS COMPUTATIONAL BIOLOGY,9(2),-e1002940.
MLA	Du, JL."Analysis of a Gene Regulatory Cascade Mediating Circadian Rhythm in Zebrafish".PLOS COMPUTATIONAL BIOLOGY 9.2(2013):-e1002940.