Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

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	Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo
	Du, JL
刊名	DEVELOPMENTAL CELL
	2012
卷号	23 期号:6 页码:1189-1202
关键词	BRAIN ZEBRAFISH CELLS REVEALS CNS MACROPHAGES ACTIVATION PARENCHYMA EXPRESSION APOPTOSIS
ISSN号	1534-5807
通讯作者	Du, JL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,forestdu@ion.ac.cn
英文摘要	Microglia are the primary immune cells in the brain. Under physiological conditions, they typically stay in a "resting" state, with ramified processes continuously extending to and retracting from surrounding neural tissues. Whether and how such highly dynamic resting microglia functionally interact with surrounding neurons are still unclear. Using in vivo time-lapse imaging of both microglial morphology and neuronal activity in the optic tectum of larval zebrafish, we found that neuronal activity steers resting microglial processes and facilitates their contact with highly active neurons. This process requires the activation of pannexin-1 hemichannels on neurons. Reciprocally, such resting microglia-neuron contact reduces both spontaneous and visually evoked activities of contacted neurons. Our findings reveal an instructive role for neuronal activity in resting microglial motility and suggest the function for microglia in homeostatic regulation of neuronal activity in the healthy brain.
学科主题	Cell Biology ; Developmental Biology
收录类别	SCI
资助信息	973 Program [2011CBA00400, 2012CB945101]; Strategic Priority Research Program [XDB02040300]; Chinese Academy of Sciences; Shanghai government [07pj14107]; General Research Fund (GRF) grants; Research Grants Council of the HKSAR [HKUST6/CRF/09]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2497]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Du, JL. Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo[J]. DEVELOPMENTAL CELL,2012,23(6):1189-1202.
APA	Du, JL.(2012).Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo.DEVELOPMENTAL CELL,23(6),1189-1202.
MLA	Du, JL."Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo".DEVELOPMENTAL CELL 23.6(2012):1189-1202.