Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior

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	Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior
	Guo, AK
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2012
卷号	423 期号:3 页码:557-563
关键词	CENTRAL-NERVOUS-SYSTEM MELANOGASTER FRUITLESS GENE EXPRESSION AROUSAL NEURONS FLY
ISSN号	0006-291X
通讯作者	Guo, AK (reprint author), Chinese Acad Sci, State Key Lab Brain & Cognit Sci, Inst Biophys, Beijing, Peoples R China.,akguo@ion.ac.cn
英文摘要	In Drosophila, dopamine plays important roles in many biological processes as a neuromodulator. Previous studies showed that dopamine level could affect fly courtship behaviors. Disturbed dopamine level leads to abnormal courtship behavior in two different ways. Dopamine up-regulation induces male-male courtship behavior, while down-regulation of dopamine level results in increased sexual attractiveness of males towards other male flies. Until now, the identity of the dopamine receptor involved in this abnormal male-male courtship behavior remains unknown. Here we used genetic approaches to investigate the role of dopamine receptors in fly courtship behavior. We found that a dopamine D-1-like receptor, DopR, was involved in fly courtship behavior. DopR mutant male flies display male-male courtship behavior. This behavior is mainly due to the male's increased propensity to court other males. Expression of functional DopR successfully rescued this mutant phenotype. Knock-down of D-2-like receptor D2R and another D-1-like receptor, DAMB, did not induce male-male courtship behavior, indicating the receptor-type specificity of this phenomenon. Our findings provide insight into a possible link between dopamine level disturbance and the induced male-male courtship behavior. (C) 2012 Elsevier Inc. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics
收录类别	SCI
资助信息	China 973 Program [2011 CBA00400]; National Science Foundation of China [30921064, 90820008, 31130027]
语种	英语
公开日期	2013-06-04
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2490]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Guo, AK. Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,423(3):557-563.
APA	Guo, AK.(2012).Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,423(3),557-563.
MLA	Guo, AK."Mutation of Drosophila dopamine receptor DopR leads to male-male courtship behavior".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 423.3(2012):557-563.