Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery

	Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery
	Zhang Z ; Gao XY ; Zhang AP ; Wu XW ; Chen L ; He CL ; Zhuang XL ; Chen XS
刊名	macromolecular chemistry and physics
	2012
卷号	213 期号:7 页码:713-719
关键词	BLOCK-COPOLYMER HYDROGELS CROSS-LINKED HYDROGEL DRUG-DELIVERY ENZYMATIC DEGRADATION CHALLENGES ADSORPTION RELEASE GROWTH
ISSN号	1022-1352
通讯作者	chen l
中文摘要	a series of ph-dependent thermo-sensitive hydrogels for oral insulin delivery is designed and synthesized. in contrast to normal ph- and thermo-sensitive hydrogels, the release of oral insulin from them is mainly controlled by the adjustable swelling ratios in gastric and intestinal juice with their variable ph sensitivity. the release behavior of loaded insulin depends on the swelling/shrinking transition because of the changing lcst at different ph values. the hydrogels presented are composed of pnipaam chains and pmaa segments and are prepared with the biodegradable acryloyl-poly(?-caprolactone)-2-hydroxylethyl methacrylate as a crosslinker. the biodegradation rates of the hydrogels are directly related to their pmaa content. in vitro release of insulin from the hydrogels is investigated and the release profiles indicate that the smart hydrogels are of great promise in phtemperature oral insulin delivery systems.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000302536900004
公开日期	2013-05-22
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/48228]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Zhang Z,Gao XY,Zhang AP,et al. Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery[J]. macromolecular chemistry and physics,2012,213(7):713-719.
APA	Zhang Z.,Gao XY.,Zhang AP.,Wu XW.,Chen L.,...&Chen XS.(2012).Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery.macromolecular chemistry and physics,213(7),713-719.
MLA	Zhang Z,et al."Biodegradable pH-Dependent Thermo-Sensitive Hydrogels for Oral Insulin Delivery".macromolecular chemistry and physics 213.7(2012):713-719.