Studies on the Chemical Transformation of 20(S)-Protopanaxatriol (PPT)-Type Ginsenosides R-e, R-g2, and R-f Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q-TOF-MS)

	Studies on the Chemical Transformation of 20(S)-Protopanaxatriol (PPT)-Type Ginsenosides R-e, R-g2, and R-f Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q-TOF-MS)
	Wu W ; Qin QJ ; Guo YY ; Sun JH ; Liu SY
刊名	journal of agricultural and food chemistry
	2012
卷号	60 期号:40 页码:10007-10014
关键词	STEAMED PANAX-NOTOGINSENG GINSENG SAPONINS PLANT-EXTRACTS IONIZATION TANDEM IDENTIFICATION RAW METABOLISM ABSORPTION EXCRETION
ISSN号	0021-8561
通讯作者	liu sy
中文摘要	a rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (rrlc-q-tof-ms) method was developed for analysis of chemical transformation of 20(s)-protopanaxatriol (ppt)-type ginsenosides r-e, r-g2, and r-f in acidic conditions. the transformation products were identified by comparing the retention time of the standard compounds, the accurate mass measurement, and the fragment ions obtained from rrlc-q-tof-tandem mass spectrometry (ms/ms) analyses. the specific product ions of aglycone ppt (m/z 475), c-24- and c-25-hydrated ppt (m/z 493), and delta 20(21) or delta 20(22) dehydration ppt (m/z 457) by ms/ms were discussed for structural characterization. experiments demonstrated that chemical transformation mechanisms of 20(s)-ppt-type ginsenosides in acidic conditions include hydrolysis of saccharide substitution, delta 20(21) or delta 20(22) dehydration, and hydration addition reactions at c-24 and c-25. the chemical transformation pathway for 20(s)-ppt-type ginsenosides was summarized. the developed rrlc-q-tof-ms method was also applied for comparative analysis of 20(s)-ppt ginsenoside and related chemical transformation products in ginseng products.
收录类别	SCI收录期刊论文
语种	英语
WOS记录号	WOS:000309566100010
公开日期	2013-04-22
内容类型	期刊论文
源URL	[http://ir.ciac.jl.cn/handle/322003/47904]
专题	长春应用化学研究所_长春应用化学研究所知识产出_期刊论文
推荐引用方式 GB/T 7714	Wu W,Qin QJ,Guo YY,et al. Studies on the Chemical Transformation of 20(S)-Protopanaxatriol (PPT)-Type Ginsenosides R-e, R-g2, and R-f Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q-TOF-MS)[J]. journal of agricultural and food chemistry,2012,60(40):10007-10014.
APA	Wu W,Qin QJ,Guo YY,Sun JH,&Liu SY.(2012).Studies on the Chemical Transformation of 20(S)-Protopanaxatriol (PPT)-Type Ginsenosides R-e, R-g2, and R-f Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q-TOF-MS).journal of agricultural and food chemistry,60(40),10007-10014.
MLA	Wu W,et al."Studies on the Chemical Transformation of 20(S)-Protopanaxatriol (PPT)-Type Ginsenosides R-e, R-g2, and R-f Using Rapid Resolution Liquid Chromatography Coupled with Quadruple-Time-of-Flight Mass Spectrometry (RRLC-Q-TOF-MS)".journal of agricultural and food chemistry 60.40(2012):10007-10014.