Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.

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	Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.
	Peng XM(彭雪梅) ; Huang LJ(黄琳娟) ; Qi CH(齐春会) ; Zhang YX(张永详) ; Tian GY(田庚元)
刊名	Chin. J. Chem.
	2001
卷号	19 期号:12 页码:1190-1197
ISSN号	1001-604X
其他题名	枸杞子糖缀合物的化学和免疫调节机理的研究
通讯作者	田庚元
英文摘要	The detailed structure of an O-glycan derived from the fruit of Lycium barbarum L. Was elucidatd based on glycosidic linkange analysis, complete and partial acid hydrolysis, ~1H-NMR and ~13C NMR spectroscopy. According to the experiments, the carbohydrate was in the form of polysacchride (arabinogalactan) chains with highly branched 3,4--galactans and terminal arabinfuranosyl substituents. The immuno-modulating mechanism of glycoconjugate and its glycan were investiganted using tritium thymidine incorporation assay, flow cytometry assay and electrophoretical mobility shift assay (EMSA). The results suggested that the immunoactive compounents of the fruit of lycium barbarum L.could enhance the splenocyte proliferation in normal mice and the effects of glycan chain were stronger than those of glycoconjugate. The target cell was most likely to be B-lymphocyte, on which existed receptor binding site acting with the glycan. In addition, the immuno-stimulatory effect of glycoconjugate (LbGp4) and its glycan (LbGp4-OL)was associated with activating the expression of nuclear factor kB(NF-kB) and activator protein 1 (AP-1)
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1002/cjoc.20010191206
语种	英语
WOS记录号	WOS:000172869400005
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22728]
专题	上海有机化学研究所_生命有机化学国家重点实验室
推荐引用方式 GB/T 7714	Peng XM,Huang LJ,Qi CH,et al. Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.[J]. Chin. J. Chem.,2001,19(12):1190-1197.
APA	彭雪梅,黄琳娟,齐春会,张永详,&田庚元.(2001).Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L..Chin. J. Chem.,19(12),1190-1197.
MLA	彭雪梅,et al."Studies on chemistry and immuno-modulating mechanism of a glycoconjugate from lycium barbarum L.".Chin. J. Chem. 19.12(2001):1190-1197.