Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides

CORC > 上海有机化学研究所 > 中国科学院上海有机化学研究所 > 中科院天然产物有机化学重点实验室

	Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides
	Zhao QW(赵启武) ; Li CZ(李超忠)
刊名	Org. Lett.
	2008
卷号	10 期号:18 页码:4037-4040
ISSN号	1523-7060
其他题名	Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides
通讯作者	李超忠
英文摘要	A general and highly efficient synthesis of 4-alkylidene-2-azetidinones was achieved by the Cu(I)-catalyzed intramolecular C-N coupling of amides with vinyl bromides. This 4-exo ring closure was found to be fundamentally preferred over other modes (5-exo, 6-exo, and 6-endo) of cyclization under copper catalysis. Tandem C-N bond formation was then successfully developed to allow the convenient generation of medium-sized lactams.
学科主题	金属有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/ol801545a
语种	英语
WOS记录号	WOS:000259197600027
公开日期	2013-03-04
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/22840]
专题	上海有机化学研究所_中科院天然产物有机化学重点实验室
推荐引用方式 GB/T 7714	Zhao QW,Li CZ. Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides[J]. Org. Lett.,2008,10(18):4037-4040.
APA	赵启武,&李超忠.(2008).Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides.Org. Lett.,10(18),4037-4040.
MLA	赵启武,et al."Preference of beta-lactam formation in Cu(I)-catalyzed intramolecular coupling of Amides with vinyl bromides".Org. Lett. 10.18(2008):4037-4040.