Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center

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	Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center
	Wen LL(温乐乐) ; Shen QL(沈其龙) ; Wan XL(万小龙) ; Lv L(吕龙)
刊名	J. Org. Chem.
	2011
卷号	76 期号:7 页码:2282-2285
ISSN号	0022-3263
其他题名	铜催化的吲哚与三氟乙烯基丙二酸酯虎克反应: 构建含三氟甲基的手性中心
通讯作者	吕龙
英文摘要	An enantioselective alkylation of indoles with trifluoroethylidene malonates catalyzed by copper(II) bis (oxazoline) complexes has been developed. The expected adducts with a stereogenic tertiary carbon center bearing a trifluoromethyl group were obtained in excellent yields (up to 99%) and ee values (up to 96% ee). The synthetic utility of this asymmetric catalytic reaction was demonstrated by the preparation of beta-CF(3)-tryptophan and 4-CF(3)-beta-carboline in high ee.
学科主题	氟化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1021/jo1024333
语种	英语
WOS记录号	WOS:000288692000039
公开日期	2013-02-25
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/19249]
专题	上海有机化学研究所_中科院有机氟化学重点实验室
推荐引用方式 GB/T 7714	Wen LL,Shen QL,Wan XL,et al. Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center[J]. J. Org. Chem.,2011,76(7):2282-2285.
APA	温乐乐,沈其龙,万小龙,&吕龙.(2011).Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center.J. Org. Chem.,76(7),2282-2285.
MLA	温乐乐,et al."Enantioselective Friedel-Crafts Alkylation of Indoles with Trifluoroethylidene Malonates by Copper-Bis(oxazoline) Complexes: Construction of Trifluoromethyl-Substituted Stereogenic Tertiary Carbon Center".J. Org. Chem. 76.7(2011):2282-2285.