Novel multiply hydrogen-bonded heterodimers based on heterocyclic ureas. Folding and stability

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	Novel multiply hydrogen-bonded heterodimers based on heterocyclic ureas. Folding and stability
	Li XQ(李晓强) ; Jiang XK(蒋锡夔) ; Wang XZ(王晓钟) ; Li ZT(黎占亭)
刊名	Tetrahedron
	2004
卷号	60 期号:9 页码:2063-2069
ISSN号	0040-4020
其他题名	基于杂环脲衍生物的多氢键异体二聚体
通讯作者	黎占亭
英文摘要	A new series of multiply hydrogen-bonded heterodimers have been self-assembled in chloroform-d, with ureidopyrimidone derivatives 2 and 3 and 2,7-diamino-1,6-naphthyridine diamide 4 and ureas 5 and 6 as monomers. The self-associating behavior of the compounds and the binding modules of the new heterodimers have been investigated. New tri-center hydrogen bonds have been proposed to explain the stability of the new heterodimers. 2D-NOESY, COSY and temperature variable H-1 NMR studies revealed that all the new heterodimers are substantially more stable than the ureidopyrimidone-based quadruply hydrogen-bonded homodimers in chloroform-d. As a result, heterodimers 2.4 and 3.4 were assembled quantitatively, while heterodimers 2.5, 3.5, 2.6, and 3.6 were formed in 80-85% yields. It is also revealed that intramolecular hydrogen bonds formed in monomers 5 and 6 reduce the stability of the corresponding heterodimers. (C) 2004 Elsevier Ltd. All rights reserved.
学科主题	物理有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1016/j.tet.2003.12.063
语种	英语
WOS记录号	WOS:000189116100012
公开日期	2013-01-16
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/12662]
专题	上海有机化学研究所_物理有机化学研究室
推荐引用方式 GB/T 7714	Li XQ,Jiang XK,Wang XZ,et al. Novel multiply hydrogen-bonded heterodimers based on heterocyclic ureas. Folding and stability[J]. Tetrahedron,2004,60(9):2063-2069.
APA	李晓强,蒋锡夔,王晓钟,&黎占亭.(2004).Novel multiply hydrogen-bonded heterodimers based on heterocyclic ureas. Folding and stability.Tetrahedron,60(9),2063-2069.
MLA	李晓强,et al."Novel multiply hydrogen-bonded heterodimers based on heterocyclic ureas. Folding and stability".Tetrahedron 60.9(2004):2063-2069.