Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence

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	Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence
	Tong XT(童孝田) ; Lan WX(蓝文贤) ; Zhang X(张许) ; Wu HM(吴厚铭) ; Liu ML(刘买利) ; Cao CY(曹春阳)
刊名	Nucleic Acids Res.
	2011
卷号	39 期号:15 页码:6753-6763
ISSN号	0305-1048
其他题名	原癌基因RET启动子序列形成的全平行的G四联体的溶液结构
通讯作者	童孝田 ; 曹春阳
英文摘要	RET protein functions as a receptor-type tyrosine kinase and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the promoter plays an important role in the transcriptional regulation of RET. Here, we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K(+) solution. The overall G-quadruplex is composed of three stacked G-tetrad and four syn guanines, which shows distinct features for all parallel-stranded folding topology. The core structure contains one G-tetrad with all syn guanines and two other with all anti-guanines. There are three double-chain reversal loops: the first and the third loops are made of 3 nt G-C-G segments, while the second one contains only 1 nt C10. These loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure and their conformations are in accord with the experimental mutations. The distinct RET promoter G-quadruplex structure suggests that it can be specifically involved in gene regulation and can be an attractive target for pathway-specific drug design.
学科主题	生命有机化学
收录类别	SCI
原文出处	http://dx.doi.org/10.1093/nar/gkr233
语种	英语
WOS记录号	WOS:000294555800044
公开日期	2013-02-21
内容类型	期刊论文
源URL	[http://202.127.28.38/handle/331003/17403]
专题	上海有机化学研究所_上海有机化学研究所
推荐引用方式 GB/T 7714	Tong XT,Lan WX,Zhang X,et al. Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence[J]. Nucleic Acids Res.,2011,39(15):6753-6763.
APA	童孝田,蓝文贤,张许,吴厚铭,刘买利,&曹春阳.(2011).Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence.Nucleic Acids Res.,39(15),6753-6763.
MLA	童孝田,et al."Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence".Nucleic Acids Res. 39.15(2011):6753-6763.