Topological structure analysis of the protein-protein interaction network in budding yeast

doi:10.1093/nar/gkg340

CORC > 计算技术研究所 > 中国科学院计算技术研究所 > 中国科学院计算技术研究所期刊论文 > 英文

	Topological structure analysis of the protein-protein interaction network in budding yeast
	Bu, DB ; Zhao, Y ; Cai, L ; Xue, H ; Zhu, XP ; Lu, HC ; Zhang, JF ; Sun, SW ; Ling, LJ ; Zhang, N
刊名	NUCLEIC ACIDS RESEARCH
	2003-05-01
卷号	31 期号:9 页码:2443-2450
ISSN号	0305-1048
DOI	10.1093/nar/gkg340
英文摘要	Interaction detection methods have led to the discovery of thousands of interactions between proteins, and discerning relevance within large-scale data sets is important to present-day biology. Here, a spectral method derived from graph theory was introduced to uncover hidden topological structures (i.e. quasi-cliques and quasi-bipartites) of complicated protein-protein interaction networks. Our analyses suggest that these hidden topological structures consist of biologically relevant functional groups. This result motivates a new method to predict the function of uncharacterized proteins based on the classification of known proteins within topological structures. Using this spectral analysis method, 48 quasi-cliques and six quasi-bipartites were isolated from a network involving 11 855 interactions among 2617 proteins in budding yeast, and 76 uncharacterized proteins were assigned functions.
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	OXFORD UNIV PRESS
WOS记录号	WOS:000182627700029
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/13622]
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, RS
作者单位	1.Chinese Acad Sci, Inst Comp Technol, Key Lab Intellignet Informat Proc, Bioinformat Res Grp, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100080, Peoples R China
推荐引用方式 GB/T 7714	Bu, DB,Zhao, Y,Cai, L,et al. Topological structure analysis of the protein-protein interaction network in budding yeast[J]. NUCLEIC ACIDS RESEARCH,2003,31(9):2443-2450.
APA	Bu, DB.,Zhao, Y.,Cai, L.,Xue, H.,Zhu, XP.,...&Chen, RS.(2003).Topological structure analysis of the protein-protein interaction network in budding yeast.NUCLEIC ACIDS RESEARCH,31(9),2443-2450.
MLA	Bu, DB,et al."Topological structure analysis of the protein-protein interaction network in budding yeast".NUCLEIC ACIDS RESEARCH 31.9(2003):2443-2450.