Integrated analysis of multiple data sources reveals modular structure of biological networks

doi:10.1016/j.bbrc.2006.04.088

CORC > 计算技术研究所 > 中国科学院计算技术研究所 > 中国科学院计算技术研究所期刊论文 > 英文

	Integrated analysis of multiple data sources reveals modular structure of biological networks
	Lu, HC ; Shi, BC ; Wu, GW ; Zhang, Y ; Zhu, XP ; Zhang, ZH ; Liu, CN ; Zhao, Y ; Wu, T ; Wang, J
刊名	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
	2006-06-23
卷号	345 期号:1 页码:302-309
关键词	integrated analysis of multiple data sources hierarchical clustering algorithm protein-protein interaction network modular structure of biological networks
ISSN号	0006-291X
DOI	10.1016/j.bbrc.2006.04.088
英文摘要	It has been a challenging task to integrate high-throughput data into investigations of the systematic and dynamic organization of biological networks. Here, we presented a simple hierarchical clustering algorithm that goes a long way to achieve this aim. Our method effectively reveals the modular structure of the yeast protein-protein interaction network and distinguishes protein complexes from functional modules by integrating high-throughput protein-protein interaction data with the added subcellular localization and expression profile data. Furthermore, we take advantage of the detected modules to provide a reliably functional context for the uncharacterized components within modules. On the other hand, the integration of various protein-protein association information makes our method robust to false-positives, especially for derived protein complexes. More importantly, this simple method can be extended naturally to other types of data fusion and provides a framework for the study of more comprehensive properties of the biological network and other forms of complex networks. (c) 2006 Elsevier Inc. All rights reserved.
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000237877700042
内容类型	期刊论文
源URL	[http://119.78.100.204/handle/2XEOYT63/10552]
专题	中国科学院计算技术研究所期刊论文_英文
通讯作者	Chen, RS
作者单位	1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing 100080, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Lu, HC,Shi, BC,Wu, GW,et al. Integrated analysis of multiple data sources reveals modular structure of biological networks[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,345(1):302-309.
APA	Lu, HC.,Shi, BC.,Wu, GW.,Zhang, Y.,Zhu, XP.,...&Chen, RS.(2006).Integrated analysis of multiple data sources reveals modular structure of biological networks.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,345(1),302-309.
MLA	Lu, HC,et al."Integrated analysis of multiple data sources reveals modular structure of biological networks".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 345.1(2006):302-309.