Controlled release of ofloxacin from chitosan-montmorillonite hydrogel

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	Controlled release of ofloxacin from chitosan-montmorillonite hydrogel
	Wang WB(王文波); Wang AQ(王爱勤)
刊名	Applied Clay Science
	2010
卷号	50 期号:1 页码:112-117
关键词	Chitosan Montmorillonite Nanocomposite Drug release Ofloxacin
ISSN号	0169-1317
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	A series of ofloxacin/montmorillonite/chitosan (OFL/MMT/CTS) hydrogels were prepared by solution intercalation and ionic crosslinking with sodium tripolyphosphate (TPP). The structure and drug loading of the beads were characterized by Fourier transform infrared spectroscopy (FTIR). The formation of intercalated nanocomposites was confirmed by X-ray diffraction (XRD). The swelling and degradation of the beads were influenced by the pH of test medium and the MMT content. Compared to pure CTS beads, the incorporation of MMT enhanced the drug entrapment, improved the swelling behavior and reduced the drug release. The CTS beads without MMT dissolved after a 3 h immersion in pH 1.2 solution. No notable disintegration was visually observed for MMT-containing beads even after a 10 h immersion. The observations suggested that the electrostatic interaction between CTS and MMT enhanced the stability of the beads and showed good potential for the use as drug carriers for sustained release.
学科主题	药物释放
收录类别	SCI
资助信息	中科院院长奖获得者科研启动专项(2008-06)
语种	英语
WOS记录号	WOS:000283617600017
公开日期	2012-09-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/130]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Wang WB,Wang AQ. Controlled release of ofloxacin from chitosan-montmorillonite hydrogel[J]. Applied Clay Science,2010,50(1):112-117.
APA	王文波,&王爱勤.(2010).Controlled release of ofloxacin from chitosan-montmorillonite hydrogel.Applied Clay Science,50(1),112-117.
MLA	王文波,et al."Controlled release of ofloxacin from chitosan-montmorillonite hydrogel".Applied Clay Science 50.1(2010):112-117.