Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium
	Wang Q(汪琴); Zhang JP(张俊平); Wang AQ(王爱勤)
刊名	Journal of Biomedical Materials Research: Part B -Applied Biomaterials
	2010
卷号	92 期号:1 页码:205-214
关键词	controlled release hydrogel in vitro smart materials
ISSN号	1552-4973
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	Layered double hydroxides (LDHs) are promising materials for the preparation of novel drug delivery matrices. To reveal the interaction between LDHs and polymers, a series of pH-sensitive sodium alginate/layered double hydroxides (SA/LDHs) hybrid beads were prepared using the simple surface crosslinking method. The SA/LDHs hybrid beads were characterized by FTIR, XRD, and SEM to study their structure and the role that LDHs play. Swelling behaviors in various aqueous solutions and drug loading as well as controlled release behavior of the SA/LDHs hybrid beads were also investigated by using diclofenac sodium (DS) as the model drug to reveal the effects of introduced LDHs. The results indicate that the positively charged LDHs layers are adsorbed on the negatively charged SA polymer chains through electrostatic interaction and act as inorganic crosslinkers in the three-dimensional network. In addition, a small part of DS molecules intercalate into layers of LDHs through an anion exchange process. The electrostatic interaction between LDHs and SA has restricted movability of the SA polymer chains, and then slows down swelling and dissolution rates of the SA/LDHs hybrid beads in aqueous solutions. The electrostatic interaction and the intercalation of DS into layers of LDHs have also improved the entrapment efficiency (EE) and controlled release behavior of SA/LDHs hybrid beads for DS.
学科主题	药物释放
收录类别	SCI
资助信息	中科院院长奖获得者科研启动专项(2008-06)
语种	英语
WOS记录号	WOS:000272896500025
公开日期	2012-09-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/116]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Wang Q,Zhang JP,Wang AQ. Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium[J]. Journal of Biomedical Materials Research: Part B -Applied Biomaterials,2010,92(1):205-214.
APA	汪琴,张俊平,&王爱勤.(2010).Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium.Journal of Biomedical Materials Research: Part B -Applied Biomaterials,92(1),205-214.
MLA	汪琴,et al."Preparation and swelling properties of pH-sensitive sodium alginate/layered double hydroxides hybrid beads for controlled release of diclofenac sodium".Journal of Biomedical Materials Research: Part B -Applied Biomaterials 92.1(2010):205-214.