In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices
	Wang AQ(王爱勤); Wang Q(汪琴); Zhang JP(张俊平)
刊名	Acta Biomaterialia
	2010
卷号	6 期号:2 页码:445-454
关键词	In situ Hydroxyapatite Nanocomposite Controlled release
ISSN号	1742-7061
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	In order to find a new way to slow down the release of drugs and to solve the burst release problem of drugs from traditionally used hydrogel matrices, a series of novel pH-sensitive sodium alginate/hydroxyapatite (SA/HA) nanocomposite beads was prepared by the in situ generation of HA micro-particles in the beads during the sol–gel transition process of SA. The SA/HA nanocomposites were characterized by Fourier transform IR spectroscopy, X-ray fluorescence spectrometry, scanning electron microscopy and field emission SEM in order to reveal their composition and surface morphology as well as the role that the in situ generated HA micro-particles play. The factors influencing the swelling behavior, drug loading and controlled release behavior of the SA/HA nanocomposite beads were also investigated using diclofenac sodium (DS) as the model drug. The HA micro-particles act as inorganic crosslinkers in the nanocomposites, which could contract and restrict the movability of the SA polymer chains, and then change the surface morphology and decrease the swell ratio. Meanwhile, the entrapment efficiency of DS was improved, and the burst release of DS was overcome. The factors (including concentration of Ca2+, reaction time and temperature) affecting the growth of HA micro-particles have a clear influence on the entrapment efficiency and release rate of DS. In this work, the nanocomposite beads prepared under optimum condition could prolong the release of DS for 8 h more compared with the pristine SA hydrogel beads.
学科主题	药物释放
收录类别	SCI
资助信息	中科院西部行动项目(KGCX2-YW-501)
语种	英语
公开日期	2012-09-02
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/115]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Wang AQ,Wang Q,Zhang JP. In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices[J]. Acta Biomaterialia,2010,6(2):445-454.
APA	王爱勤,汪琴,&张俊平.(2010).In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices.Acta Biomaterialia,6(2),445-454.
MLA	王爱勤,et al."In situ generation of sodium alginate/hydroxyapatite nanocomposite beads as drug controlled release matrices".Acta Biomaterialia 6.2(2010):445-454.