Composite hydrogel beads based on chitosan and laponite: preparation, swelling, and drug release behaviour

CORC > 兰州化学物理研究所 > 中国科学院兰州化学物理研究所 > 环境材料与生态化学研究发展中心

	Composite hydrogel beads based on chitosan and laponite: preparation, swelling, and drug release behaviour
	Wang WB(王文波); Wang AQ(王爱勤)
刊名	Iranian Polymer Journal
	2011
卷号	20 期号:6 页码:479-490
关键词	chitosan Laponite composite drug release Ofloxacin
ISSN号	1026-1265
通讯作者	王爱勤 aqwang@licp.cas.cn
中文摘要	Biopolymer/layered silicate composites have shown unique advantages and potentials for the passive targeting of drugs because they can overcome the burst drawbacks of organic carrier, increase the drug utilization and enhance the controllable capability of drug release. Furthermore, the biocompatibility and nontoxicity of biopolymers is retained, and therefore it is promising and applicable in pharmaceutical fields. The main research aim of this work was to develop a series of biopolymer/layered silicate composite beads based on chitosan (CTS) and Laponite (LA) by a simple ionic cross-linking reaction using sodium tripolyphosphate as the cross-linker. The resultant beads were characterized by Fourier transform infrared spectroscopy, scanning electronic microscope and X-ray diffraction analysis. The swelling behaviour in physiological pH solutions (7.4 and 1.2), drug encapsulation efficiency and controlled release behaviour were also investigated by using Ofloxacin as the model drug to reveal the effects of introduced LA. The results indicate that the incorporation of LA remarkably improved the swelling behaviour, enhanced the drug entrapment efficiency, and slowed down the drug release behaviour in contrast to the pure organic CTS beads. The exfoliated LA clay could act as a physical cross-linker to facilitate the formation of network structure between the CTS and LA. It is suggested that LA may be developed as an effective additive for fabricating a sustained drug delivery system.
学科主题	功能高分子
收录类别	SCI
资助信息	中科院西部行动项目(KGCX2-YW-501)
语种	英语
WOS记录号	WOS:000292660900002
公开日期	2012-08-30
内容类型	期刊论文
源URL	[http://210.77.64.217/handle/362003/77]
专题	兰州化学物理研究所_环境材料与生态化学研究发展中心
推荐引用方式 GB/T 7714	Wang WB,Wang AQ. Composite hydrogel beads based on chitosan and laponite: preparation, swelling, and drug release behaviour[J]. Iranian Polymer Journal,2011,20(6):479-490.
APA	王文波,&王爱勤.(2011).Composite hydrogel beads based on chitosan and laponite: preparation, swelling, and drug release behaviour.Iranian Polymer Journal,20(6),479-490.
MLA	王文波,et al."Composite hydrogel beads based on chitosan and laponite: preparation, swelling, and drug release behaviour".Iranian Polymer Journal 20.6(2011):479-490.