PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation

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	PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation
	Yang, F ; He, XP ; Feng, LY ; Mizuno, K ; Liu, XW ; Russell, J ; Xiong, WC ; Lu, B
刊名	NATURE NEUROSCIENCE
	2001
卷号	4 期号:1 页码:19-28
关键词	LONG-TERM POTENTIATION DEVELOPING NEUROMUSCULAR SYNAPSES NEUROTROPHIN SIGNAL-TRANSDUCTION NERVE GROWTH-FACTOR BDNF KNOCKOUT MICE PHOSPHATIDYLINOSITOL 3-KINASE HIPPOCAMPAL-NEURONS CORTICAL-NEURONS TRANSMISSION RECEPTOR
ISSN号	1097-6256
通讯作者	Lu, B (reprint author), NICHD, Unit Synapse Dev & Plast, Dev Neurobiol Lab, NIH, Bethesda, MD 20892 USA,
英文摘要	Signaling mechanisms underlying neurotrophic regulation of synaptic transmission are not fully understood. Here we show that neurotrophin-3 (NT3)-induced potentiation of synaptic transmission at the neuromuscular synapses is blocked by inhibition of phosphoinositide-3 kinase, phospholipase C-gamma or the downstream IP3 receptors of phospholipase C-gamma, but not by inhibition of MAP kinase. However, neither stimulation of Ca2+ release from intracellular stores by photolysis of caged IP3, nor expression of a constitutively active phosphoinositide-3 kinase (PI3K(star)) in presynaptic motoneurons alone is sufficient to enhance transmission. Photo-uncaging of IP3 in neurons expressing PI3K(star) elicits a marked synaptic potentiation, mimicking the NT3 effect. These results reveal an involvement of PI3 kinase in transmitter release, and suggest that concomitant activation of PI3 kinase and IP3 receptors is both necessary and sufficient to mediate the NTS-induced synaptic potentiation.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/2082]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yang, F,He, XP,Feng, LY,et al. PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation[J]. NATURE NEUROSCIENCE,2001,4(1):19-28.
APA	Yang, F.,He, XP.,Feng, LY.,Mizuno, K.,Liu, XW.,...&Lu, B.(2001).PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation.NATURE NEUROSCIENCE,4(1),19-28.
MLA	Yang, F,et al."PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation".NATURE NEUROSCIENCE 4.1(2001):19-28.