Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells

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	Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells
	Duan, KL ; Yu, X ; Zhang, C ; Zhou, ZA
刊名	JOURNAL OF NEUROSCIENCE
	2003
卷号	23 期号:35 页码:11235-11243
关键词	action potential code secretion capacitance calcium patch-clamp chromaffin cell LONG-TERM POTENTIATION ROOT GANGLION NEURONS CALCIUM-CHANNELS NEUROTRANSMITTER RELEASE NEUROENDOCRINE CELLS HIPPOCAMPAL SYNAPSES TRANSMITTER RELEASE PYRAMIDAL NEURONS CA2+ INFLUX EXOCYTOSIS
ISSN号	0270-6474
通讯作者	Zhou, ZA (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,
英文摘要	Action potentials (APs) are the principal physiological stimuli for neurotransmitter secretion in neurons. Most studies on stimulus secretion coupling have been performed under voltage clamp using artificial electrical stimuli. To investigate the modulatory effects of AP codes on neural secretion, we introduce a capacitance method to study AP-induced secretion in single cells. The action potential pattern was defined by a four-parameter "code function:" F(n, m, f, d). With this method, cell secretion evoked by stimulation with an AP code was quantified in real time by membrane capacitance (C-m) in adrenal chromaffin cells. We found, in addition to AP frequency (f), for a given number of APs, another parameter of the AP code, the number of AP bursts (m) in which the set of APs occurs, can effectively modulate cell secretion. Possible mechanisms of the m effect are depletion of the readily releasable pool and inactivation of Ca2+ channels during a burst of APs. The physiological m effect may play a key role in AP-mediated neural information transfer within a single neuron and among the elements of a neural network.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1991]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Duan, KL,Yu, X,Zhang, C,et al. Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells[J]. JOURNAL OF NEUROSCIENCE,2003,23(35):11235-11243.
APA	Duan, KL,Yu, X,Zhang, C,&Zhou, ZA.(2003).Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells.JOURNAL OF NEUROSCIENCE,23(35),11235-11243.
MLA	Duan, KL,et al."Control of secretion by temporal patterns of action potentials in adrenal chromaffin cells".JOURNAL OF NEUROSCIENCE 23.35(2003):11235-11243.