Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study

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	Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study
	Yu, YQ ; Xiong, Y ; Chan, YS ; He, JF
刊名	JOURNAL OF NEUROSCIENCE
	2004
卷号	24 期号:12 页码:3060-3069
关键词	corticofugal modulation the medial geniculate body electrical stimulation in vivo intracellular recording excitatory postsynaptic potential EPSP inhibitory postsynaptic potential IPSP low-threshold calcium spike MEDIAL GENICULATE-BODY NUCLEUS RETICULARIS THALAMI BIG BROWN BAT CORTICOTHALAMIC PROJECTIONS RECEPTOR ACTIVATION CELLULAR MECHANISMS INFERIOR COLLICULUS CORTICAL ACTIVATION MAMMALIAN THALAMUS SOUND STIMULATION
ISSN号	0270-6474
通讯作者	He, JF (reprint author), Hong Kong Polytech Univ, Dept Rehabil Sci, Kowloon, Hong Kong, Peoples R China,rsjufang@polyu.edu.hk
英文摘要	In the present study, we investigated the auditory responses of the medial geniculate (MGB) neurons, through in vivo intracellular recordings of anesthetized guinea pigs, while the auditory cortex was electrically activated. Of the 63 neurons that received corticofugal modulation of the membrane potential, 30 received potentiation and 33 received hyperpolarization. The corticofugal potentiation of the membrane potential (amplitude, mean +/- SD, 8.6 +/- 5.5 mV; duration, 125.5 +/- 75.4 msec) facilitated the auditory responses and spontaneous firing of the MGB neurons. The hyperpolarization of - 11.3 +/- 4.9 mV in amplitude and 210.0 +/- 210.1 msec in duration suppressed the auditory responses and spontaneous firing of the MGB neurons. Four of the five neurons that were histologically confirmed to be located in the lemniscal MGB received corticofugal facilitatory modulation, and all of the four neurons that were confirmed to be located in the non-lemniscal MGB received corticofugal inhibitory modulation. The present intracellular recording provides novel results on how the corticofugal projection gates the sensory information in the thalamus: via the spatially selective depolarization of lemniscal MGB neurons and hyperpolarization of non-lemniscal MGB neurons. It is speculated that the systematic selectivity of facilitation and inhibition over the lemniscal and non-lemniscal MGB is related to the attention shift within the auditory modality and across the sensory modalities.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1970]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yu, YQ,Xiong, Y,Chan, YS,et al. Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study[J]. JOURNAL OF NEUROSCIENCE,2004,24(12):3060-3069.
APA	Yu, YQ,Xiong, Y,Chan, YS,&He, JF.(2004).Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study.JOURNAL OF NEUROSCIENCE,24(12),3060-3069.
MLA	Yu, YQ,et al."Corticofugal Gating of auditory information in the thalamus: An in vivo intracellular recording study".JOURNAL OF NEUROSCIENCE 24.12(2004):3060-3069.