Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion

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	Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion
	Yu, WY ; Guo, W ; Feng, LY
刊名	FEBS LETTERS
	2004
卷号	577 期号:40910 页码:87-92
关键词	lipid raft Nogo66 Nogo66 receptor p75 signal transduction cholesterol depletion MYELIN-ASSOCIATED GLYCOPROTEIN CELL-ADHESION MOLECULES NERVE GROWTH CONES NEURITE OUTGROWTH NOGO-66 RECEPTOR DEPENDENT RECRUITMENT AXONAL REGENERATION ANCHORED PROTEINS MEMBRANE DOMAINS P75 RECEPTOR
ISSN号	0014-5793
通讯作者	Feng, LY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China,lyfeng@sibs.ac.cn
英文摘要	NogoA, a myelin-associated component, inhibits neurite outgrowth. Nogo66, a portion of NogoA, binds to Nogo66 receptor (NgR) and induces the inhibitory signaling. LINGO-1 and p75 neurotrophin receptor (p75), the low-affinity nerve growth factor receptor, are also required for NogoA signaling. However, signaling mechanisms downstream to Nogo receptor remain poorly understood. Here, we observed that NgR and p75 were colocalized in low-density membrane raft fractions derived from forebrains and cerebella as well as from cerebellar granule cells. NgR interacted with p75 in lipid rafts. In addition, disruption of lipid rafts by beta-methylcyclodextrin, a cholesterol-binding reagent, reduced the Nogo66 signaling. Our results suggest an important role of lipid rafts in facilitating the interaction between NgRs and provide insight into mechanisms underlying the inhibition of neurite outgrowth by NogoA. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
学科主题	Biochemistry & Molecular Biology ; Biophysics ; Cell Biology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1936]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Yu, WY,Guo, W,Feng, LY. Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion[J]. FEBS LETTERS,2004,577(40910):87-92.
APA	Yu, WY,Guo, W,&Feng, LY.(2004).Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion.FEBS LETTERS,577(40910),87-92.
MLA	Yu, WY,et al."Segregation of Nogo66 receptors into lipid rafts in rat brain and inhibition of Nogo66 signaling by cholesterol depletion".FEBS LETTERS 577.40910(2004):87-92.