N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus

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	N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus
	Pei, DS ; Guan, QH ; Sun, YF ; Zhang, QX ; Xu, TL(徐天乐) ; Zhang, GY
刊名	NEUROSCIENCE LETTERS
	2005
卷号	391 期号:40910 页码:38-42
关键词	cerebral ischemia mixed lineage kinase-3 (MLK3) postsynaptic density protein 95 (PSD-95) N-acetylcysteine (NAC) POSTSYNAPTIC DENSITY PROTEIN-95 CEREBRAL-ISCHEMIA ACTIVATION IDENTIFICATION PHOSPHORYLATION SPRK PATHWAY BEARING FAMILY REGION
ISSN号	0304-3940
通讯作者	Zhang, GY (reprint author), Univ Sci & Technol China, Sch Life Sci, Dept Neurobiol & Biophys, Hefei 230027, Peoples R China,gyzhang@xzmc.edu.cn
英文摘要	Mixed lineage kinase-3 (MLK3) is a recently described member of the MLK subfamily of Ser/Thr protein kinases that interacts with mitogen-activated protein kinase (MAPK) pathways. In this study, we investigated the translocation of MLK3 during transient cerebral ischemia in rat hippocampus. Transient brain ischernia was induced by the four-vessel occlusion in Sprague-Dawley rats. Our data show that MLK3 can translocate from cytosolic fraction to the membrane fraction during ischernia and the increased MLK3 in the membrane fraction bind to postsynaptic density protein 95 (PSD-95). The antioxidant N-acetylcysteine (NAC) could inhibit the translocation of MLK3 from cytosolic fraction to the membrane fraction and decrease the interactions of MLK3 and PSD-95 in the membrane fraction. Consequently, these results indicate that reactive oxygen species (ROS) was closely associated with MLK3 translocation induced by transient global ischernia in rat hippocampus. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1858]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Pei, DS,Guan, QH,Sun, YF,et al. N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus[J]. NEUROSCIENCE LETTERS,2005,391(40910):38-42.
APA	Pei, DS,Guan, QH,Sun, YF,Zhang, QX,Xu, TL,&Zhang, GY.(2005).N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus.NEUROSCIENCE LETTERS,391(40910),38-42.
MLA	Pei, DS,et al."N-acetylcysteine inhibit the translocation of mixed lineage kinase-3 from cytosol to plasma membrane during transient brain ischemia in rat hippocampus".NEUROSCIENCE LETTERS 391.40910(2005):38-42.