Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke

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	Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke
	Wang, Wei
刊名	JOURNAL OF NEUROSCIENCE RESEARCH
	2007
卷号	85 期号:8 页码:1637-1646
关键词	focal cerebral ischemia running CREB phosphorylation newborn cells survival hippocampus-dependent memory FOCAL CEREBRAL-ISCHEMIA ELEMENT-BINDING PROTEIN LONG-TERM POTENTIATION ENVIRONMENTAL ENRICHMENT NEUROTROPHIC FACTOR ADULT-MOUSE HIPPOCAMPAL NEUROGENESIS STIMULATES NEUROGENESIS CELL-PROLIFERATION PHYSICAL-ACTIVITY
ISSN号	0360-4012
通讯作者	Zhu, DY (reprint author), Nanjing Med Univ, Sch Pharm, Dept Pharmacol, Nanjing, Peoples R China,dyzhu@njmu.edu.cn
英文摘要	Spatial cognitive impairment is common after stroke insults. Voluntary exercise could improve the impaired spatial memory. Newly generated neurons in the dentate gyrus are necessary for the acquisition of new hippocampus-dependent memories. However, it is not well known whether voluntary exercise after stroke promotes neurogenesis in the adult clentate gyrus, thereby promoting spatial memory recovery. Here, we examined in mice subjected to focal cerebral ischemia the effect of voluntary or forced exercise on neurogenesis in the ischemic clentate gyrus and spatial memory. Exposure to voluntary wheel running after stroke enhanced newborn cell survival and up-regulated the phosphorylation of cAMP response element binding protein (CREB) in the clentate gyrus and reversed ischemia-induced spatial memory impairment. However, the enhanced newborn cell survival and CREB phosphorylation in the clentate gyrus and improved spatial memory were not observed in the mice exposed to forced swimming. Moreover, there was a significant correlation between the total number of surviving newborn cells in the dentate gyrus and the ability of mice to locate the platform in the Morris water maze. These results suggest that, in the adult mice, exposure to voluntary exercise after ischemic stroke may promote newborn cells survival in the dentate gyrus by up-regulating CREB phosphorylation and consequently restore impaired hippocampus-dependent memory. (c) 2007 Wiley-Liss, Inc.
学科主题	Neurosciences & Neurology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1768]
专题	上海神经科学研究所_神经所(总) 上海神经科学研究所_视知觉机制研究组
推荐引用方式 GB/T 7714	Wang, Wei. Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2007,85(8):1637-1646.
APA	Wang, Wei.(2007).Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke.JOURNAL OF NEUROSCIENCE RESEARCH,85(8),1637-1646.
MLA	Wang, Wei."Voluntary exercise-induced neurogenesis in the postischemic dentate gyrus is associated with spatial memory recovery from stroke".JOURNAL OF NEUROSCIENCE RESEARCH 85.8(2007):1637-1646.