Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system
	Dai, Jin-Xia ; Hu, Ze-Lan ; Shi, Ming ; Guo, Chao ; Ding, Yu-Qiang
刊名	JOURNAL OF COMPARATIVE NEUROLOGY
	2008
卷号	509 期号:4 页码:341-355
关键词	localization brain Tlx3 postanatal development in situ hybridization immunohistochemistry NAIL-PATELLA SYNDROME VERTEBRATE LIMB DEVELOPMENT SPINAL-CORD SEROTONERGIC NEURONS SENSORY NEURONS GENE EXPRESSION PROTEIN BRAIN REQUIRES
ISSN号	0021-9967
通讯作者	Ding, YQ (reprint author), Chinese Acad Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,dingyq@ion.ac.cn
英文摘要	The expression profile of Lim homeodomain transcription factor Lmx1b in the mouse brain was investigated at different postnatal stages by immunohistochemistry and in situ hybridization. At postnatal day (P) 7, many Lmx1b-expressing neurons were found in the posterior hypothalamic area, supramammillary nucleus, ventral premammillary nucleus, and subthalamic nucleus. In the midbrain, numerous Lmx1b-expressing neurons were present in the substantia nigra pars compacta and ventral tegmental area. In the hindbrain, Lmx1b-expressing neurons were primarily observed in the raphe nuclei, parabrachial nuclei, principal sensory trigeminal nucleus, nucleus of the solitary tract, and laminae I-II of the medullary dorsal horn as well as spinal dorsal horn. Although expression levels diminished as postnatal life progressed, persistent expression throughout the first year of life was observed in many of these regions. In contrast, Lmx1b was present in a few brain regions (e.g., principal sensory trigeminal nucleus) only in early life with expression expiring by P60. Lmx1b was observed in dopaminergic neurons in the midbrain and serotonergic neurons in the hindbrain, as determined by double labeling with specific markers. In addition, we found that Lmx1b-expressing neurons are got GABAergic, and Lmx1b was colocalized with T1x3 in the parabrachial nuclei, principal sensory trigeminal nucleus, nucleus of the solitary tract. as well as the medullary and spinal dorsal horns, suggesting that Lmx1b-expressing cells in these areas are excitatory neurons. Our data suggest that Lmx1b is involved in the postnatal maturation of certain types of neurons and maintenance of their normal functions in the adult brain.
学科主题	Neurosciences & Neurology ; Zoology
收录类别	SCI
语种	英语
公开日期	2012-07-23
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1707]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Dai, Jin-Xia,Hu, Ze-Lan,Shi, Ming,et al. Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system[J]. JOURNAL OF COMPARATIVE NEUROLOGY,2008,509(4):341-355.
APA	Dai, Jin-Xia,Hu, Ze-Lan,Shi, Ming,Guo, Chao,&Ding, Yu-Qiang.(2008).Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system.JOURNAL OF COMPARATIVE NEUROLOGY,509(4),341-355.
MLA	Dai, Jin-Xia,et al."Postnatal ontogeny of the transcription factor Lmx1b in the mouse central nervous system".JOURNAL OF COMPARATIVE NEUROLOGY 509.4(2008):341-355.