Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control

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	Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control
	Xu, Tian-Le(徐天乐) ; Duan, Bo
刊名	PROGRESS IN NEUROBIOLOGY
	2009
卷号	87 期号:3 页码:171-180
关键词	Acid-sensing ion channel Nociceptive Central sensitization Ca(2+) SPINAL DORSAL-HORN AMPA RECEPTOR SUBUNITS SENSORY NEURONS SYNAPTIC PLASTICITY INFLAMMATORY PAIN CAPSAICIN RECEPTOR NITRIC-OXIDE CENTRAL SENSITIZATION CHEMICAL NOCICEPTION GLUTAMATE RECEPTORS
ISSN号	0301-0082
通讯作者	Xu, TL (reprint author), Chinese Acad Sci, Inst Neurosci, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
英文摘要	The development of chronic pain involves increased sensitivity of peripheral nociceptors and elevated neuronal activity in many regions of the central nervous system. Much of these changes are caused by the amplification of nociceptive signals resulting from the modulation and altered expression of specific ion channels and receptors in the central and peripheral nervous system. Understanding the processes by which these ion channels and receptors are regulated and how these mechanisms malfunction may lead to new treatments for chronic pain. Here we review the contribution of the Ca(2+)-permeable acid-sensing ion channel (ASIC(Ca)) in the development and persistence of chronic pain, and the potential underlying mechanisms. Accumulating evidence suggests that ASIC(Ca) represents an attractive new target for developing effective therapies for chronic pain. (c) 2009 Elsevier Ltd. All rights reserved.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30830035, 30621062]; National Basic Research Program of China[2006CB500803]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1682]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Xu, Tian-Le,Duan, Bo. Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control[J]. PROGRESS IN NEUROBIOLOGY,2009,87(3):171-180.
APA	Xu, Tian-Le,&Duan, Bo.(2009).Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control.PROGRESS IN NEUROBIOLOGY,87(3),171-180.
MLA	Xu, Tian-Le,et al."Calcium-permeable acid-sensing ion channel in nociceptive plasticity: A new target for pain control".PROGRESS IN NEUROBIOLOGY 87.3(2009):171-180.