Reduction of Dopamine Level Enhances the Attractiveness of Male Drosophila to Other Males

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	Reduction of Dopamine Level Enhances the Attractiveness of Male Drosophila to Other Males
	Liu, Tong ; Dartevelle, Laurence ; Yuan, Chunyan ; Wei, Hongping ; Wang, Ying ; Ferveur, Jean-Francois ; Guo, Aike
刊名	PLOS ONE
	2009
卷号	4 期号:2 页码:e4574-e4575
ISSN号	1932-6203
通讯作者	Liu, T (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, State Key Lab Neurosci, Inst Neurosci, Shanghai, Peoples R China,jean-francois.ferveur@u-bourgogne.fr ; akguo@ion.ac.cn
英文摘要	Dopamine is an important neuromodulator in animals and its roles in mammalian sexual behavior are extensively studied. Drosophila as a useful model system is widely used in many fields of biological studies. It has been reported that dopamine reduction can affect female receptivity in Drosophila and leave male-female courtship behavior unaffected. Here, we used genetic and pharmacological approaches to decrease the dopamine level in dopaminergic cells in Drosophila, and investigated the consequence of this manipulation on male homosexual courtship behavior. We find that reduction of dopamine level can induce Drosophila male-male courtship behavior, and that this behavior is mainly due to the increased male attractiveness or decreased aversiveness towards other males, but not to their enhanced propensity to court other males. Chemical signal input probably plays a crucial role in the male-male courtship induced by the courtees with reduction of dopamine. Our finding provides insight into the relationship between the dopamine reduction and male-male courtship behavior, and hints dopamine level is important for controlling Drosophila courtship behavior.
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
资助信息	National Science Foundation of China[30270341, 30630028, 30621004]; Multidisciplinary Research Program (Brain and Mind) of the Chinese Academy of Sciences; Major State Basic Research Program[G20000 77800, 2006CB806600, 2006CB911003]; Precedent Project of Important Intersectional Disciplines in the Knowledge Innovation Engineering Department of the Chinese Academy of Sciences[KJCX1-09-03, KSCX2-YW-R-28]; CNRS; Burgundy Regional Council
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1677]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Liu, Tong,Dartevelle, Laurence,Yuan, Chunyan,et al. Reduction of Dopamine Level Enhances the Attractiveness of Male Drosophila to Other Males[J]. PLOS ONE,2009,4(2):e4574-e4575.
APA	Liu, Tong.,Dartevelle, Laurence.,Yuan, Chunyan.,Wei, Hongping.,Wang, Ying.,...&Guo, Aike.(2009).Reduction of Dopamine Level Enhances the Attractiveness of Male Drosophila to Other Males.PLOS ONE,4(2),e4574-e4575.
MLA	Liu, Tong,et al."Reduction of Dopamine Level Enhances the Attractiveness of Male Drosophila to Other Males".PLOS ONE 4.2(2009):e4574-e4575.