GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation

CORC > 上海神经科学研究所 > 中国科学院上海生命科学研究院神经科学研究所 > 神经所(总)

	GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation
	Gong, Neng ; Li, Yong ; Cai, Guo-Qiang ; Niu, Rui-Fang ; Fang, Qi ; Wu, Kun ; Chen, Zhong ; Lin, Long-Nian ; Xu, Lin ; Fei, Jian ; Xu, Tian-Le(徐天乐)
刊名	JOURNAL OF NEUROSCIENCE
	2009
卷号	29 期号:50 页码:15836-15845
关键词	INHIBITORY SYNAPTIC POTENTIALS AMINOBUTYRIC-ACID UPTAKE DENTATE GYRUS IN-VIVO RAT INDUCTION MICE NEURONS MEMORY LTP
ISSN号	0270-6474
通讯作者	Xu, TL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China,tlxu@ion.ac.cn
英文摘要	The network oscillation and synaptic plasticity are known to be regulated by GABAergic inhibition, but how they are affected by changes in the GABA transporter activity remains unclear. Here we show that in the CA1 region of mouse hippocampus, pharmacological blockade or genetic deletion of GABA transporter-1 (GAT1) specifically impaired long-term potentiation (LTP) induced by theta burst stimulation, but had no effect on LTP induced by high-frequency stimulation or long-term depression induced by low-frequency stimulation. The extent of LTP impairment depended on the precise burst frequency, with significant impairment at 3-7 Hz that correlated with the time course of elevated GABAergic inhibition caused by GAT1 disruption. Furthermore, in vivo electrophysiological recordings showed that GAT1 gene deletion reduced the frequency of hippocampal theta oscillation. Moreover, behavioral studies showed that GAT1 knock-out mice also exhibited impaired hippocampus-dependent learning and memory. Together, these results have highlighted the important link between GABAergic inhibition and hippocampal theta oscillation, both of which are critical for synaptic plasticity and learning behaviors.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30621062, 30830035]; National Basic Research Program of China[2006CB500803]; Chinese Academy of Sciences[KSCX2-YW-R-35, KSCX2-YW-R-100]; China Postdoctoral Science Foundation; Shanghai Postdoctoral Scientific Program
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1624]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Gong, Neng,Li, Yong,Cai, Guo-Qiang,et al. GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation[J]. JOURNAL OF NEUROSCIENCE,2009,29(50):15836-15845.
APA	Gong, Neng.,Li, Yong.,Cai, Guo-Qiang.,Niu, Rui-Fang.,Fang, Qi.,...&Xu, Tian-Le.(2009).GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation.JOURNAL OF NEUROSCIENCE,29(50),15836-15845.
MLA	Gong, Neng,et al."GABA Transporter-1 Activity Modulates Hippocampal Theta Oscillation and Theta Burst Stimulation-Induced Long-Term Potentiation".JOURNAL OF NEUROSCIENCE 29.50(2009):15836-15845.