The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons

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	The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons
	Li, Ning ; Zhao, Chun-Tao ; Wang, Ying ; Yuan, Xiao-Bing
刊名	PLOS ONE
	2010
卷号	5 期号:5 页码:e10596-e10597
关键词	CCAAT DISPLACEMENT PROTEIN CELL-CYCLE EXIT HOMEODOMAIN PROTEIN HOMEOBOX GENE CEREBRAL-CORTEX RHO-GTPASES P27(KIP1) EXPRESSION SUBVENTRICULAR ZONE TRANSGENIC MICE DROSOPHILA CUT
ISSN号	1932-6203
通讯作者	Li, N (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Neurosci, Shanghai, Peoples R China,yuanxb@ion.ac.cn
英文摘要	In the murine cerebral cortex, mammalian homologues of the Cux family transcription factors, Cux1 and Cux2, have been identified as restricted molecular markers for the upper layer (II-IV) pyramidal neurons. However, their functions in cortical development are largely unknown. Here we report that increasing the intracellular level of Cux1, but not Cux2, reduced the dendritic complexity of cultured cortical pyramidal neurons. Consistently, reducing the expression of Cux1 promoted the dendritic arborization in these pyramidal neurons. This effect required the existence of the DNA-binding domains, hence the transcriptional passive repression activity of Cux1. Analysis of downstream signals suggested that Cux1 regulates dendrite development primarily through suppressing the expression of the cyclin-dependent kinase inhibitor p27(Kip1), and RhoA may mediate the regulation of dendritic complexity by Cux1 and p27. Thus, Cux1 functions as a negative regulator of dendritic complexity for cortical pyramidal neurons.
学科主题	Life Sciences & Biomedicine - Other Topics
收录类别	SCI
资助信息	National Basic Research Program of China[2006CB943903]; National Natural Science Foundation of China[30625023]; Chinese Academy of Sciences[KSCX2-YW-R-103]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1593]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Li, Ning,Zhao, Chun-Tao,Wang, Ying,et al. The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons[J]. PLOS ONE,2010,5(5):e10596-e10597.
APA	Li, Ning,Zhao, Chun-Tao,Wang, Ying,&Yuan, Xiao-Bing.(2010).The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons.PLOS ONE,5(5),e10596-e10597.
MLA	Li, Ning,et al."The Transcription Factor Cux1 Regulates Dendritic Morphology of Cortical Pyramidal Neurons".PLOS ONE 5.5(2010):e10596-e10597.