Statistical Comparison of Spike Responses to Natural Stimuli in Monkey Area V1 With Simulated Responses of a Detailed Laminar Network Model for a Patch of V1

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	Statistical Comparison of Spike Responses to Natural Stimuli in Monkey Area V1 With Simulated Responses of a Detailed Laminar Network Model for a Patch of V1
	Rasch, Malte J. ; Schuch, Klaus ; Logothetis, Nikos K. ; Maass, Wolfgang
刊名	JOURNAL OF NEUROPHYSIOLOGY
	2011
卷号	105 期号:2 页码:757-778
关键词	PRIMARY VISUAL-CORTEX LOCAL-FIELD POTENTIALS LATERAL GENICULATE-NUCLEUS OCULAR DOMINANCE COLUMNS RETINAL GANGLION-CELLS MACAQUE STRIATE CORTEX CORTICAL-NEURONS COMPLEX CELLS INTRACELLULAR-RECORDINGS FUNCTIONAL ARCHITECTURE
ISSN号	0022-3077
通讯作者	Rasch, MJ (reprint author), Chinese Acad Sci, Inst Neurosci, Yue Yang Rd 320, Shanghai, Peoples R China,malte@ion.ac.cn
英文摘要	Rasch MJ, Schuch K, Logothetis NK, Maass W. Statistical comparison of spike responses to natural stimuli in monkey area V1 with simulated responses of a detailed laminar network model for a patch of V1. J Neurophysiol 105: 757-778, 2011. First published November 24, 2010; doi:10.1152/jn.00845.2009. A major goal of computational neuroscience is the creation of computer models for cortical areas whose response to sensory stimuli resembles that of cortical areas in vivo in important aspects. It is seldom considered whether the simulated spiking activity is realistic (in a statistical sense) in response to natural stimuli. Because certain statistical properties of spike responses were suggested to facilitate computations in the cortex, acquiring a realistic firing regimen in cortical network models might be a prerequisite for analyzing their computational functions. We present a characterization and comparison of the statistical response properties of the primary visual cortex (V1) in vivo and in silico in response to natural stimuli. We recorded from multiple electrodes in area V1 of 4 macaque monkeys and developed a large state-of-the-art network model for a 5 x 5-mm patch of V1 composed of 35,000 neurons and 3.9 million synapses that integrates previously published anatomical and physiological details. By quantitative comparison of the model response to the "statistical fingerprint" of responses in vivo, we find that our model for a patch of V1 responds to the same movie in a way which matches the statistical structure of the recorded data surprisingly well. The deviation between the firing regimen of the model and the in vivo data are on the same level as deviations among monkeys and sessions. This suggests that, despite strong simplifications and abstractions of cortical network models, they are nevertheless capable of generating realistic spiking activity. To reach a realistic firing state, it was not only necessary to include both N-methyl-D-aspartate and GABA(B) synaptic conductances in our model, but also to markedly increase the strength of excitatory synapses onto inhibitory neurons (>2-fold) in comparison to literature values, hinting at the importance to carefully adjust the effect of inhibition for achieving realistic dynamics in current network models.
学科主题	Neurosciences & Neurology ; Physiology
收录类别	SCI
资助信息	Austrian Science Fund (FWF)[S9102-N13]; European Union[FP6-015879, FP7-231267, FP7-243914]; German Academic Exchange Service
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1555]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Rasch, Malte J.,Schuch, Klaus,Logothetis, Nikos K.,et al. Statistical Comparison of Spike Responses to Natural Stimuli in Monkey Area V1 With Simulated Responses of a Detailed Laminar Network Model for a Patch of V1[J]. JOURNAL OF NEUROPHYSIOLOGY,2011,105(2):757-778.
APA	Rasch, Malte J.,Schuch, Klaus,Logothetis, Nikos K.,&Maass, Wolfgang.(2011).Statistical Comparison of Spike Responses to Natural Stimuli in Monkey Area V1 With Simulated Responses of a Detailed Laminar Network Model for a Patch of V1.JOURNAL OF NEUROPHYSIOLOGY,105(2),757-778.
MLA	Rasch, Malte J.,et al."Statistical Comparison of Spike Responses to Natural Stimuli in Monkey Area V1 With Simulated Responses of a Detailed Laminar Network Model for a Patch of V1".JOURNAL OF NEUROPHYSIOLOGY 105.2(2011):757-778.