Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death

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	Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death
	Wang, Yi-Zhi ; Xu, Tian-Le(徐天乐)
刊名	MOLECULAR NEUROBIOLOGY
	2011
卷号	44 期号:3 页码:350-358
关键词	Acidosis ASIC1a Neuronal cell death Spermine Ischemic stroke EXTRACELLULAR ACIDOSIS H-1-NMR SPECTROSCOPY HUNTINGTONS-DISEASE SYNAPTIC-TRANSMISSION SPREADING DEPRESSION HIPPOCAMPAL-NEURONS PARKINSONS-DISEASE ALZHEIMERS-DISEASE ENDOTHELIAL-CELLS GABA(A) RECEPTORS
ISSN号	0893-7648
通讯作者	Xu, TL (reprint author), Shanghai Jiao Tong Univ, Sch Med, Div Neurosci, Dept Biochem & Mol Cell Biol,Inst Med Sci, 280 S Chongqing Rd, Shanghai 200025, Peoples R China,xu-happiness@shsmu.edu.cn
英文摘要	Acidosis is a common feature of many neuronal diseases and often accompanied with adverse consequences such as pain and neuronal injury. Before the discovery of acid-sensing ion channels (ASICs), protons were usually considered as a modulator of other ion channels, such as voltage-gated calcium channels, N-methyl-d-aspartate, and gamma-amino butyric acid(A) receptor channels. Accordingly, the functional effects of acidosis were considered as consequences of modulations of these channels. Since the first cloning of ASICs in 1997, the conventional view on acidosis-mediated pain and cell injury has been dramatically changed. To date, ASICs, which are directly activated by extracellular protons, are shown to mediate most of the acidosis-associated physiological and pathological functions. For example, ASIC1a channels are reported to mediate acidosis-induced ischemic neuronal death. In this article, we will review the possible mechanisms that underlie ASIC1a channel-mediated neuronal death and discuss ASIC1a channel modulators involved in this process.
学科主题	Neurosciences & Neurology
收录类别	SCI
资助信息	National Natural Science Foundation of China[30830035]; National Basic Research Program of China[2011CBA00408]; Shanghai Municipal Government[09XD1404900]
语种	英语
公开日期	2012-07-13
内容类型	期刊论文
源URL	[http://ir.sibs.ac.cn/handle/331001/1520]
专题	上海神经科学研究所_神经所(总)
推荐引用方式 GB/T 7714	Wang, Yi-Zhi,Xu, Tian-Le. Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death[J]. MOLECULAR NEUROBIOLOGY,2011,44(3):350-358.
APA	Wang, Yi-Zhi,&Xu, Tian-Le.(2011).Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death.MOLECULAR NEUROBIOLOGY,44(3),350-358.
MLA	Wang, Yi-Zhi,et al."Acidosis, Acid-Sensing Ion Channels, and Neuronal Cell Death".MOLECULAR NEUROBIOLOGY 44.3(2011):350-358.